Mechanisms of desensitization of β-adrenergic receptors
For the past several years we and our colleagues have been involved in a study of catecholamine-induced desensitization of the β-adrenergic receptor (βAR)-linked adenylate cyclase system. There appears to be a number of processes utilized by cells to reduce responsiveness to catecholamines (see Lefkowitz et al., 1980; Perkins et al., 1982; Harden, 1983; Hertel & Perkins, 1985 for recent reviews). Our studies have focused on a desensitization process that is βAR-specific, that is, it results in changes in the system that eliminate responsiveness only to catecholamines.
KeywordsSucrose Lymphoma Sedimentation Polypeptide Catecholamine
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