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Mechanisms of desensitization of β-adrenergic receptors

  • J. P. Perkins
  • T. K. Harden

Abstract

For the past several years we and our colleagues have been involved in a study of catecholamine-induced desensitization of the β-adrenergic receptor (βAR)-linked adenylate cyclase system. There appears to be a number of processes utilized by cells to reduce responsiveness to catecholamines (see Lefkowitz et al., 1980; Perkins et al., 1982; Harden, 1983; Hertel & Perkins, 1985 for recent reviews). Our studies have focused on a desensitization process that is βAR-specific, that is, it results in changes in the system that eliminate responsiveness only to catecholamines.

Keywords

Adenylate Cyclase Adrenergic Receptor Adenylate Cyclase Activity Adenylate Cyclase System Frog Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Macmillan Publishers Limited 1984

Authors and Affiliations

  • J. P. Perkins
    • 1
  • T. K. Harden
  1. 1.Department of PharmacologyUniversity of North Carolina at Chapel HillUSA

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