Cellular and Molecular Pharmacology of the Anthrapyrazole Antitumour Agents

  • Laurence H. Patterson
  • David R. Newell
Part of the Topics in Molecular and Structural Biology book series (TMSB)


The development of the anthrapyrazole antitumour agents may yet be one of the major achievements of developmental cancer chemotherapy in the 1980s. As with many synthetic or semisynthetic DNA binding agents, the rationale for the synthesis of the anthrapyrazoles stemmed from the desire to identify a drug with equivalent antitumour activity to that of doxorubicin (Figure 2.1, I) yet without the cumulative dose-limiting cardiotoxicity which has consistently been a feature of anthracycline chemotherapy. As discussed later in this chapter, early clinical data suggest that at least one of the anthrapyrazoles has significant single-agent antitumour activity in patients and three compounds remain in clinical trials.


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  • Laurence H. Patterson
  • David R. Newell

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