Galanin pp 331-341 | Cite as

On the interations of galanin within the hypothalamic-pituitary axis of the rat

  • J. I. Koenig
  • S. C. Hooi
  • D. M. Maiter
  • J. B. Martin
  • S. M. Gabriel
  • R. M. Strauss
  • L. M. Kaplan
Part of the Wenner-Gren Center International Symposium Series book series


The hypothalamus has been shown to be densely populated by galanin-containing neuron cell bodies. The greatest concentration of cells reside in the arcuate nucleus. In addition, galanin immunopositive cells are present in the paraventricular (PVN), supraoptic (SON) and dorsomedial nuclei (Rokaeus et al., 1984; Ch’ng et al., 1985; Skofitsch et al., 1985; Melander et al., 1985, 1986; Palkovits et al., 1987). Galanin-containing nerve fibers are found throughout the hypothalamus but the median eminence (ME) contains the highest concentration of galanin in the brain (Skofitsch et al., 1986; Gabriel et al., 1988). Autoradiographic binding studies also demonstrated that galanin receptors are concentrated in the ME (Melander et al., 1986; Skofitsch et al., 1987). Much of the galanin in the ME originates in the arcuate nucleus (Gabriel et al., 1988) but the PVN and SON also contribute substantial amounts of galanin to the ME (Palkovits et al., 1987). Furthermore, Levin et al. (1987) and Holets et al. (1988) demonstrated that brainstem neurons containing galanin project to both the PVN and SON. These inputs probably relay hemodynamic information to these nuclei.


Median Eminence Arcuate Nucleus Anterior Pituitary Cell ACTH Secretion Galanin Receptor 
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Copyright information

© The Wenner-Gren Center 1991

Authors and Affiliations

  • J. I. Koenig
  • S. C. Hooi
  • D. M. Maiter
  • J. B. Martin
  • S. M. Gabriel
  • R. M. Strauss
  • L. M. Kaplan

There are no affiliations available

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