Abstract
Phencyclidine (1-(1-phenylcyclohexyl)-piperidine (PCP)) is a drug with anaesthetic and psychotomimetic properties (Hayes and Balster, 1985). It has been shown that metaphit (1-1-(3-isothiocyanatophenyl-cyclohexylpiperidine), a derivative of PCP, in in vitro studies irreversibly binds to the PCP site of PCP/NMDA (N-methyl-D-aspartate) receptor, presumably by an acylation process (Rafferty et al., 1985). Recently, in in vivo studies, metaphit has been found to induce audiogenic seizure in mice (Debler et al., 1989).
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References
Debler, E. A., Lipovac, M. N., Lajtha, A., Zloković, B. V., Jacobson, A. E., Rice, K. C. and Reith, M. E. A. (1989). Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice. Europ. J. Pharmacol., 165, 155–159
Hayes, B. A. and Balster, R. L. (1985). Anticonvulsant properties of phencyclidine-like drugs in mice. Europ. J. Pharmacol., 117, 121–123
Rafferty, M. F., Mattson, M., Jacobson, A. E. and Rice, K. C. (1985). A specific acylating agent for the (3H)phencyclidine receptors in rat brain. FEBS Lett., 181, 318–321
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Lipovac, M.N. et al. (1992). Epileptogenic Activity of Metaphitinduced Audiogenic Seizure in Small Rodents. In: Segal, M.B. (eds) Barriers and Fluids of the Eye and Brain. Palgrave, London. https://doi.org/10.1007/978-1-349-12306-3_16
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DOI: https://doi.org/10.1007/978-1-349-12306-3_16
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-12308-7
Online ISBN: 978-1-349-12306-3
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