Drainage of Cerebrospinal Fluid During Development and in Congenital Hydrocephalus
Cerebrospinal fluid is secreted in the cerebral ventricles by the choroid plexuses. It flows through the ventricular system to the foramina in the fourth ventricle and around the subarachnoid space to the drainage sites. Obstructions within the CSF flow pathway, such as developmental abnormalities, haemorrhage and tumours, can cause hydrocephalus by the accumulation of excess CSF in the ventricles. The classical view of CSF drainage is that it takes place through the arachnoid villi in the wall of the cranial venous sinuses (Weed, 1914), although additional routes exist, such as spinal arachnoid villi (Welch and Pollay, 1963) and lymphatic pathways (Weed, 1914; Bradbury and Cole, 1980).
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