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Therapeutic Monoclonal Antibodies pp 95–108Cite as

Palgrave Macmillan

Mouse Antibodies to Carcinomas

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Abstract

Many monoclonal antibodies (Mabs) have been created by immunizing mice with human carcinomas. In the vast majority of cases, these Mabs define tumor-associated differentiation antigens (TADAs), which have relative but not absolute specificity for neoplastic cells (Reisfeld, 1986; Roth, 1986; Sikorska, Shuster, and Gold, 1988; Bast, 1989; K. E. Hellström and Hellström, 1989a). Although more tumor-specific Mabs would be preferable, many potential therapeutic uses of the Mabs are already available, and several have been tested clinically and given promising results.

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  1. Karl Erik Hellström
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Carl A. K. Borrebaeck James W. Larrick

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Hellström, K.E., Hellström, I. (1990). Mouse Antibodies to Carcinomas. In: Borrebaeck, C.A.K., Larrick, J.W. (eds) Therapeutic Monoclonal Antibodies. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-11894-6_6

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