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Experimental Models in the Study of the Pathology of the Blood-Brain Barrier

  • Hugh Davson
  • Berislav Zloković
  • Ljubisa Rakić
  • Malcolm B. Segal
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Abstract

Transport across the blood-brain barrier has a protective and regulatory role, and in this chapter we shall consider some behavioural dysfunctions that may be related to a disturbance of the barrier. The prerequisite for studies on barrier dysfunction is the establishment of suitable experimental animal models. Many, but far from all, models in experimental medicine are homologous, i.e. there is a correspondence in the aetiology of the disease and the model. Other models, on the other hand, may be described as only isomorphic, so that, despite a parallelism between the model and the human condition, the cause of the condition in the model may be quite different from that in man. Finally, the model may have no resemblance to the disease but simply be a non-homologous or non-isomorphic representation that has value in either reflecting some aspects of the disease or for studying the therapy used for treating the disease.

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Copyright information

© The authors 1993

Authors and Affiliations

  • Hugh Davson
    • 1
  • Berislav Zloković
    • 2
  • Ljubisa Rakić
    • 3
  • Malcolm B. Segal
    • 1
  1. 1.Sherrington School of Physiology UMDSGuy’s and St Thomas’s HospitalsLondonUK
  2. 2.USC School of MedicineLos AngelesUSA
  3. 3.School of MedicineBelgradeSerbia

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