Transport of Some Precursors of Nucleotides and Some Vitamins
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The transport of nucleotide precursors, such as the purine and pyrimidine bases and their sugar derivatives, the nucleosides, within the central nervous system is of some interest, since nucleic acid synthesis, although limited in extent within the central nervous system, certainly takes place; and at least some precursors must be derived from the blood (Spector and Eells, 1984). The matter is of clinical interest because the Lesch-Nyhan syndrome, involving neurological and behavioural disturbances, is associated with a deficiency of the enzyme that converts the purine hypoxanthine to nucleoside, namely hypoxanthine-guanine phosphoribosyl transferase.
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