Transport of Some Precursors of Nucleotides and Some Vitamins

  • Hugh Davson
  • Berislav Zloković
  • Ljubisa Rakić
  • Malcolm B. Segal


The transport of nucleotide precursors, such as the purine and pyrimidine bases and their sugar derivatives, the nucleosides, within the central nervous system is of some interest, since nucleic acid synthesis, although limited in extent within the central nervous system, certainly takes place; and at least some precursors must be derived from the blood (Spector and Eells, 1984). The matter is of clinical interest because the Lesch-Nyhan syndrome, involving neurological and behavioural disturbances, is associated with a deficiency of the enzyme that converts the purine hypoxanthine to nucleoside, namely hypoxanthine-guanine phosphoribosyl transferase.


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Copyright information

© The authors 1993

Authors and Affiliations

  • Hugh Davson
    • 1
  • Berislav Zloković
    • 2
  • Ljubisa Rakić
    • 3
  • Malcolm B. Segal
    • 1
  1. 1.Sherrington School of Physiology UMDSGuy’s and St Thomas’s HospitalsLondonUK
  2. 2.USC School of MedicineLos AngelesUSA
  3. 3.School of MedicineBelgradeSerbia

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