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5-HT1A Receptors in Anxiety

  • Chapter
New Concepts in Anxiety

Abstract

Brain 5-HT receptors have been classified in at least six subtypes (5-HT1A, 1B, 1C, 1D, 2 AND 3; Peroutka, 1988), among which the 5-HT1A subtype has been the focus of intense research during the last few years. This receptor type is located both presynaptically on the 5-HT cell bodies (somatodendritic receptors), predominantly in the dorsal and median raphe nuclei and postsynaptically, predominantly in the limbic system (Verge et al., 1985; Weissmann-Nanopoulos et al., 1985). Activation of presynaptic 5-HT1A receptors with 5-HT1A ligands inhibits serotonergic neurotransmission (Hamon et al., 1988; Hjorth and Magnusson, 1988; Sharp et al., 1989a, b) and the physiological role of these receptors is probably to provide the brain with an autoinhibitory feedback system controlling 5-HT neurotransmission. At the postsynaptic level, activation of 5-HT1A receptors results in neuronal inhibition, the consequences of which are not well understood (e.g. Sprouse and Aghajanian, 1988; Martin and Mason, 1987).

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Author information

Authors and Affiliations

  1. Institute for Neurobiology, Troponwerke GmbH & Co. KG, Berliner Straße 156, D-5000, Köln80, West Germany

    J. De Vry

Authors
  1. J. De Vry
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  2. T. Glaser
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  3. T. Schuurman
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  4. R. Schreiber
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  5. J. Traber
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Editor information

Editors and Affiliations

  1. Pierre Fabre Médicament, Castres, France

    M. Briley

  2. Psychopharmacology Research Unit, UMDS, Guy’s Hospital, London, SE1 9RT, UK

    S. E. File

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© 1991 Macmillan Publishers Limited

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De Vry, J., Glaser, T., Schuurman, T., Schreiber, R., Traber, J. (1991). 5-HT1A Receptors in Anxiety. In: Briley, M., File, S.E. (eds) New Concepts in Anxiety. Palgrave, London. https://doi.org/10.1007/978-1-349-11847-2_7

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  • DOI: https://doi.org/10.1007/978-1-349-11847-2_7

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-11849-6

  • Online ISBN: 978-1-349-11847-2

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