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5-HT Receptor Mechanisms in Human Anxiety

  • Chapter
New Concepts in Anxiety

Abstract

5-HT has been implicated in the mechanisms of anxiety since the seminal studies of Graeff and Schoenfeld (1970) and Geller and Blum (1970). They showed that 5-HT receptor antagonists and inhibition of 5-HT synthesis prevented the ability of foot shock to suppress operant behaviour. The subsequent observation that the anxiolytic benzodiazepine oxazepam decreased 5-HT turnover lead to the suggestion that anxiolytic drugs work by inhibition of 5-HT function (Wise et al., 1972).

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Author information

Authors and Affiliations

  1. University Department of Psychiatry, Withington Hospital, Manchester, M20 8RL, UK

    J. F. W. Deakin

Authors
  1. J. F. W. Deakin
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  2. F. S. Guimarães
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  3. M. Wang
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  4. J. Hellewell
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  5. R. Hensman
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Editor information

Editors and Affiliations

  1. Pierre Fabre Médicament, Castres, France

    M. Briley

  2. Psychopharmacology Research Unit, UMDS, Guy’s Hospital, London, SE1 9RT, UK

    S. E. File

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© 1991 Macmillan Publishers Limited

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Deakin, J.F.W., Guimarães, F.S., Wang, M., Hellewell, J., Hensman, R. (1991). 5-HT Receptor Mechanisms in Human Anxiety. In: Briley, M., File, S.E. (eds) New Concepts in Anxiety. Palgrave, London. https://doi.org/10.1007/978-1-349-11847-2_6

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  • DOI: https://doi.org/10.1007/978-1-349-11847-2_6

  • Publisher Name: Palgrave, London

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  • Online ISBN: 978-1-349-11847-2

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