Atrial Natriuretic Factors and the Central Nervous System: Receptors and Functions

  • Jean-Guy Chabot
  • RÉMi Quirion
  • Gerard Morel
Chapter

Abstract

Mammalian atrial cardiocytes contain storage granules which morphologically resemble those found in other cells producing peptide hormones. These granules have been shown to contain a natriuretic and diuretic factor (De Bold, 1982; Garcia et al, 1982). This factor is the 126 arnino acid atrial natriuretic factor (ANF) propeptide, which, in its mature form, is a 28 amino acid circulating peptide in both rat and human (Cantin and Genest, 1985; De Bold, 1985; Anderson and Bloom, 1986; Atlas, 1987). This active peptide hormone has potent biological effects on the peripheral vascular tone, and on the regulation of fluid and electrolyte balance (Cantin and Genest, 1985; De Bold, 1985; Anderson and Bloom, 1986; Atlas, 1987; Goetz, 1988). Many of the established actions of ANF have been first described using crude atrial extracts or partially purified preparations. These effects have now been confirmed using pure synthetic peptides. In addition to natriuresis, diuresis and vasorelaxation, ANF-like peptides induce a variety of biological effects in different target tissues. For example, they modulate aldosterone production as well as vasopressin and androgen release (Bex and Corbin, 1985; Cantin and Genest, 1985; De Bold, 1985; Anderson and Bloom, 1986; Pandey et al., 1986; Mukhopadhyay et al, 1986; Atlas, 1987; Goetz, 1988). It is now clear that ANF actions are mediated by highly selective and specific ANF receptor sites localized on plasma membranes as well as inside the cells of target tissues (De Lean et al, 1984; Napier et al, 1984; Morel and Heisler, 1988).

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Copyright information

© Macmillan Publishers Limited 1990

Authors and Affiliations

  • Jean-Guy Chabot
    • 1
  • RÉMi Quirion
    • 1
  • Gerard Morel
    • 2
  1. 1.Douglas Hospital Research Centre and Department of PsychiatryMcGill UniversityVerdunCanada
  2. 2.UA559, Laboratoire d’Histologie et Embryologie, Faculté de Médecine Lyon-SudCNRSOullinsFrance

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