Abstract
Cardiovascular disease is the major cause of mortality in the western world. Since hypertension has been identified as a potent risk factor for both stroke and myocardial infarction,1,2 it is not surprising that many drugs which reduce blood pressure are already in widespread clinical use, with more under preclinical investigation, or at the stage of Phase I trials. The results from the major hypertension trials confirm that blood pressure reduction lowers the incidence of stroke, even in mild hypertension, and by the percentage expected for a direct relationship between hypertension and stroke.3 However, blood pressure reduction has proved singularly disappointing in prevention of myocardial infarction.4–7
Morals do not forbid making experiments on one’s neighbour or on one’s self. … Among the experiments that may be tried on man, those that can only harm are forbidden, those that are innocent are permissible and those that may do good are obligatory.
Claude Bernard, 1865
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Cockcroft, J.R., Webb, D.J. (1990). Phase I Trials on Anti-hypertensive Drugs. In: O’Grady, J., Linet, O.I. (eds) Early Phase Drug Evaluation in Man. Palgrave, London. https://doi.org/10.1007/978-1-349-10705-6_24
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DOI: https://doi.org/10.1007/978-1-349-10705-6_24
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