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New Concepts in Cancer pp 74–92Cite as

The Control of Cell Movement by Laminin, and its Role in Metastasis

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Abstract

Laminin is a structural glycoprotein in basement membranes (Timpl et al., 1979). It participates in the control of a variety of cell functions including movement (Vlodavsky and Gospodarowicz, 1981; Situ et al., 1984; Goodman and Newgreen, 1985; Ocalan et al., 1988), growth, differentiation (Manthorpe et al., 1983) and shape. Not surprisingly, this molecule has been found implicated in biological situations which imply cell migration, tissue remodeling and phenotype fluctuation, such as embryogenesis (Ekblom et al., 1980; Sanes, 1985) or malignancy. On the basis of our experience we review the main factors in laminin control of cell movement.

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Authors
  1. J. C. Lissitzky
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  2. M. Bouzon
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  3. P. Delori
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  4. C. Bignon
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  5. P. Cantau
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  6. P. M. Martin
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Editor information

Editors and Affiliations

  1. Pierre Fabre Médicament, Castres, France

    C. Etievant

  2. CNRS, Toulouse, France

    J. Cros

  3. Roswell Park Memorial Hospital, Buffalo, NY, USA

    Y. M. Rustum

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© 1990 Macmillan Publishers Limited

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Lissitzky, J.C., Bouzon, M., Delori, P., Bignon, C., Cantau, P., Martin, P.M. (1990). The Control of Cell Movement by Laminin, and its Role in Metastasis. In: Etievant, C., Cros, J., Rustum, Y.M. (eds) New Concepts in Cancer. Palgrave, London. https://doi.org/10.1007/978-1-349-10671-4_6

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  • DOI: https://doi.org/10.1007/978-1-349-10671-4_6

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