Abstract
At the time when peripheral 5-hydroxytryptamine (5-HT) receptors were first classified, by Gaddum and Picarelli (1957), the complex nature of the enteric nervous system (ENS) was not appreciated, although many of the essential and distinguishing characteristics of that division of the autonomic nervous system (ANS) had already been published. The pioneering experiments of Bayliss and Starling (1899), in vivo, and Trendelenburg (1917), in vitro, established that all of the components of the peristaltic reflex arc, including pressure receptors, primary sensory neurones, interneurones and excitatory and inhibitory motor neurones, are present in the gut as intrinsic elements of the ENS. Because of this enteric autonomy, and because of the matching anatomical discrepancy between a very large number of neurones in the enteric ganglia and a very small number of pre-ganglionic fibres in the diaphragmatic vagus nerves, Langley (1921) classified the ENS as the third division of the ANS. Nevertheless, despite all the evidence showing that most enteric neurones receive no direct input from the CNS, many texts in 1957 continued to treat enteric ganglia simply as parasympathetic relays.
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Gershon, M.D., Mawe, G.M., Branchek, T.A. (1989). Multiple 5-HT Receptors in the Enteric Nervous System. In: Mylecharane, E.J., Angus, J.A., de la Lande, I.S., Humphrey, P.P.A. (eds) Serotonin. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10114-6_5
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