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Serotonin pp 21-30 | Cite as

5-HT Receptors on Afferent Neurones

  • B. P. Richardson
  • G. Engel
  • P. Donatsch
  • K. -H Buchheit
Part of the Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology book series (SSNIC)

Abstract

Receptors for 5-hydroxytryptamine (5-HT) are widely distributed over the mammalian peripheral nervous system (Wallis, 1981; Fozard, 1984). Those located on afferent neurones generally mediate excitatory actions of 5-HT, with neuronal inhibition being only rarely encountered (Paintal, 1973; Wallis, 1981; Roberts, 1984; Higashi and Nishi, 1982). Until recently it was unclear which receptor subtype mediates the stimulant action of 5-HT on primary afferent neurones, because such responses are refractory to blockade by the older, classical 5-HT receptor antagonists such as methysergide or cyproheptadine (Fozard, 1984). However, the recent discovery of new agonist and antagonist drugs with a high degree of selectivity for the different 5-HT receptor subtypes (Bradley et al., 1986; Richardson and Engel, 1986; Saxena et al., 1986) has stimulated renewed interest in this topic.

Keywords

Carotid Body Nodose Ganglion Carotid Sinus Nerve Flare Response Afferent Neurone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The editors and contributors 1989

Authors and Affiliations

  • B. P. Richardson
    • 1
  • G. Engel
    • 1
  • P. Donatsch
    • 1
  • K. -H Buchheit
    • 1
  1. 1.Preclinical Research DepartmentSandoz LimitedBaselSwitzerland

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