Abstract
The history of the development of our overall understanding of the classification of receptors for 5-hydroxytryptamine (5-HT) was extensively discussed by the participants at the workshop on 5-HT receptor classification. The general consensus was that, despite major recent advances, a clear picture has yet to emerge because specific drug tools are not available to characterize definitively all the known/putative 5-HT receptor types. Furthermore, although all the workshop participants expressed a general desire to collate data from functional studies with data from ligand binding studies, this is not always as easy as it has been with the 5-HT2 receptor. Nevertheless, despite these shortcomings, it was agreed that the attempted all-embracing 5-HT receptor classification of Bradley et al. (1986) still provided a framework of understanding on which to build. Indeed, the majority of new data presented reinforced the classification, although some observations were difficult to encompass within it.
This overview incorporates material presented during the classification of 5-HT receptors and binding sites session, and material discussed in a workshop chaired by the authors; an attempt has been made to reflect all the views expressed and not just those of the authors (see acknowledgements).
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Humphrey, P.P.A., Richardson, B.P. (1989). Classification of 5-HT Receptors and Binding Sites: An Overview. In: Mylecharane, E.J., Angus, J.A., de la Lande, I.S., Humphrey, P.P.A. (eds) Serotonin. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10114-6_26
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