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Cardiac Actions of 5-Hydroxytryptamine

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Serotonin

Abstract

Most animals respond to the i.v. administration of 5-hydroxytryptamine (5-HT) initially with a decrease in heart rate, generally via similar mechanisms and receptors. In isolated heart preparations or in whole animals without vagal influences, 5-HT usually increases heart rate and, sometimes, cardiac contractility, but a variety of mechanisms and receptors appear to be involved in different species. Although the cardiac effects of 5-HT have been studied extensively, the precise nature of the receptors involved is emerging only now (Saxena, 1986). This is particularly due to the availability of selective drug tools and the characterization of 5-HT receptor subtypes into 5-HT1-like, 5-HT2 and 5-HT3 receptors (see Bradley et al., 1986). This present article reviews the mechanisms and the nature of the 5-HT receptors mediating the cardiac effects of 5-HT (Table 15.1).

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands

    P. R. Saxena

Authors
  1. P. R. Saxena
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Sydney, Australia

    Ewan J. Mylecharane

  2. Baker Medical Research Institute, Prahran, Australia

    James A. Angus

  3. Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia

    Ivan S. de la Lande

  4. Glaxo Group Research Ltd, Ware, England

    Patrick P. A. Humphrey

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© 1989 The editors and contributors

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Saxena, P.R. (1989). Cardiac Actions of 5-Hydroxytryptamine. In: Mylecharane, E.J., Angus, J.A., de la Lande, I.S., Humphrey, P.P.A. (eds) Serotonin. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10114-6_15

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