Abstract
The presence of 5-HT3 receptor-mediated responses in peripheral tissues is well established. Their presence in the CNS is implied by the powerful behavioural effects produced by 5-HT3 receptor antagonists in laboratory animals (Costall et al., 1987a, b; Jones et al., 1987, 1988; Tyers et al., 1987). However, despite the high selectivity of action of these compounds for the 5-HT3 receptor, there is no direct evidence that 5-HT3 receptors are present in the brain. Three series of experiments have been conducted to address this issue: functional studies on central 5-HT pathways; effects on mesolimbic dopamine metabolism; and binding studies with a novel [3H]-labelled 5-HT3 receptor antagonist.
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References
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Tyers, M.B., Costall, B., Naylor, R.J. (1989). 5-HT3 Receptors in the Central Nervous System. In: Mylecharane, E.J., Angus, J.A., de la Lande, I.S., Humphrey, P.P.A. (eds) Serotonin. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10114-6_12
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DOI: https://doi.org/10.1007/978-1-349-10114-6_12
Publisher Name: Palgrave Macmillan, London
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