Abstract
The existence of two brain dopamine (DA) receptor subtypes (D-1 and D-2) has now gained widespread acceptance. More recently, it has been reported that D-1 and D-2 receptors in normosensitive striatum are functionally linked (Barone et al., 1986). The use of the D-2 selective agonist, bromocriptine, in previously untreated parkinsonian patients has been reported to induce little or no dyskinesia (Lees and Stern, 1981). The interaction between D-1 and D-2 receptors in treatment of Parkinson’s disease may therefore be important particularly for the induction of dyskinesia observed after therapy with L-DOPA, a mixed DA agonist.
This research was supported by the Parkinson Foundation of Canada and Sandoz Canada. Participation to this symposium was financed by the Government of Quebec and Sandoz Canada.
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References
Barone, P., Davis, T.A., Braun, A.R. and Chase, T.N. (1986). Dopaminergic mechanisms and motor function: characterization of D-1 and D-2 dopamine receptor interactions. Eur. J. Pharmacol., 123, 109–114.
Bédard, P.J., Di Paolo, T., Falardeau, P. and Boucher, R. (1986). Chronic treatment with Levodopa, but not bromocriptine induces dyskinesia in MPTP-parkinsonian monkeys. Correlation with [3H]spiperone binding. Brain Res., 379, 294–299.
Lees, A.J. and Stern, G.M. (1981). Sustained bromocriptine therapy in previously untreated patients with Parkinson’s disease. J. Neurol. Neurosurg. Psychiat., 44, 1020–1023.
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© 1988 T. Di Paolo, P. Falardeau and P. Bédard
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Di Paolo, T., Falardeau, P., BĂ©dard, P. (1988). Effect of Chronic Levodopa, Bromocriptine and SKF-38393 on Dyskinesia and Dopamine Receptors in MPTP-parkinsonian Monkeys. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_60
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DOI: https://doi.org/10.1007/978-1-349-10047-7_60
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