Effect of Chronic Levodopa, Bromocriptine and SKF-38393 on Dyskinesia and Dopamine Receptors in MPTP-parkinsonian Monkeys

  • T. Di Paolo
  • P. Falardeau
  • P. Bédard
Part of the Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology book series (SSNIC)

Abstract

The existence of two brain dopamine (DA) receptor subtypes (D-1 and D-2) has now gained widespread acceptance. More recently, it has been reported that D-1 and D-2 receptors in normosensitive striatum are functionally linked (Barone et al., 1986). The use of the D-2 selective agonist, bromocriptine, in previously untreated parkinsonian patients has been reported to induce little or no dyskinesia (Lees and Stern, 1981). The interaction between D-1 and D-2 receptors in treatment of Parkinson’s disease may therefore be important particularly for the induction of dyskinesia observed after therapy with L-DOPA, a mixed DA agonist.

Keywords

Dopamine Neurol MPTP Bromocriptine Tetrahydropyridine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barone, P., Davis, T.A., Braun, A.R. and Chase, T.N. (1986). Dopaminergic mechanisms and motor function: characterization of D-1 and D-2 dopamine receptor interactions. Eur. J. Pharmacol., 123, 109–114.CrossRefPubMedGoogle Scholar
  2. Bédard, P.J., Di Paolo, T., Falardeau, P. and Boucher, R. (1986). Chronic treatment with Levodopa, but not bromocriptine induces dyskinesia in MPTP-parkinsonian monkeys. Correlation with [3H]spiperone binding. Brain Res., 379, 294–299.CrossRefPubMedGoogle Scholar
  3. Lees, A.J. and Stern, G.M. (1981). Sustained bromocriptine therapy in previously untreated patients with Parkinson’s disease. J. Neurol. Neurosurg. Psychiat., 44, 1020–1023.PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© T. Di Paolo, P. Falardeau and P. Bédard 1988

Authors and Affiliations

  • T. Di Paolo
    • 1
    • 2
  • P. Falardeau
    • 1
    • 2
  • P. Bédard
    • 3
  1. 1.School of PharmacyLaval UniversityQuebecCanada
  2. 2.Department of Molecular EndocrinologyLaval University Medical CenterQuebecCanada
  3. 3.Neurobiology Laboratory, Department of AnatomyLaval UniversityQuebecCanada

Personalised recommendations