Abstract
The D2 subtype of dopamine (DA) receptor is known to play important roles in hormone secretion, motor function and clinical syndromes, and D2 agonists are finding increasing use in clinical medicine (Meitzer, 1980; Schachter et al., 1980; Stoof and Kebabian, 1984; Seeman and Grigordiadis, 1987). D2 agonists exhibit wide structural diversity and recently several structure activity relationship (SAR) studies have attempted to define the molecular requirements essential for dopaminergic activity (Cannon, 1985). Such SAR studies can provide insights into the chemomorphology of the D2 receptor macromolecular complex. Although a number of receptor models have been proposed, most have not attempted to examine every class of DA agonist (for review see, Katerinopoulos and Schuster, 1987).
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© 1988 Philip M. Beart and David T. Manallack
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Beart, P.M., Manallack, D.T. (1988). Structural Analyses Predict the Primary Pharmacophore and Secondary Sites for the D2 Receptor. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_6
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DOI: https://doi.org/10.1007/978-1-349-10047-7_6
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