Abstract
In rats and mice withdrawn from repeated morphine injections the turnover of cerebral dopamine is decreased, but acute morphine administration clearly increases it (Ahtee and Attila, 1987). However, injections subject the animals to stressful stimuli such as restraint and cutaneous pain. On the other hand, stress is known to alter the turnover of cerebral dopamine. Furthermore, the animals might undergo repeated partial withdrawals between injections. These problems could be avoided by oral self-administration by drinking.
This research was supported by USPHS Grant DA 02226 (KRC) and by the Research Council for Medicine of the Academy of Finland.
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References
Ahtee, L. and Attila, L.M.J. (1987). Cerebral monoamine neurotransmitters in opioid withdrawal and dependence. Medical Biology, 65, 113–119.
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© 1988 L. Ahtee, L.M.J. Attila, K.R. Carlson and H. Haikala
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Ahtee, L., Attila, L.M.J., Carlson, K.R., Haikala, H. (1988). Changes in Brain Dopamine Metabolism During Withdrawal from Chronic Oral Self-administration of Morphine, and in Response to a Morphine Challenge in the Withdrawn State. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_44
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