Uptake and Release of Dopamine from Rat Striatal Slices: Comparison of PCP, Amphetamine and Nomifensine

  • Linda P. Dwoskin
  • Greg A. Gerhardt
  • Carla J. Drebing
  • Cindy C. Wilcox
  • Nancy R. Zahniser
Part of the Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology book series (SSNIC)

Abstract

Phencyclidine (PCP) is an abused drug which produces untoward side-effects (violent behavior, hallucinations and paranoia) resembling certain forms of schizophrenia (Rawson et al., 1981). Understanding its mechanism of action may lead to the development of therapies to block its side-effects and may provide a basis for understanding the causes of schizophrenia.

Keywords

EDTA Dopamine Schizophrenia Serotonin Catecholamine 

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References

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Copyright information

© Linda P. Dwoskin, Greg A. Gerhardt, Carla J. Drebing, Cindy C. Wilcox and Nancy R. Zahniser 1988

Authors and Affiliations

  • Linda P. Dwoskin
    • 1
  • Greg A. Gerhardt
    • 1
  • Carla J. Drebing
    • 1
  • Cindy C. Wilcox
    • 1
  • Nancy R. Zahniser
    • 1
  1. 1.Departments of Pharmacology and PsychiatryUniversity of Colorado Health Sciences CenterDenverUSA

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