Uptake and Release of Dopamine from Rat Striatal Slices: Comparison of PCP, Amphetamine and Nomifensine
Phencyclidine (PCP) is an abused drug which produces untoward side-effects (violent behavior, hallucinations and paranoia) resembling certain forms of schizophrenia (Rawson et al., 1981). Understanding its mechanism of action may lead to the development of therapies to block its side-effects and may provide a basis for understanding the causes of schizophrenia.
KeywordsEDTA Dopamine Schizophrenia Serotonin Catecholamine
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- Smith, R.C, Meitzer, H.Y., Arora, R.C. and Davis, J.M. (1977). Effects of phencyclidine on [3H]-catecholamine and [3H]-serotonin uptake in synaptosomal preparations from rat brain. Biochem. Pharmacol., 26, 1435–1439.Google Scholar