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Unique Effects of Long-term Clozapine, but not Haloperidol, on Dopamine Transmission in the Amygdaloid Complex

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Pharmacology and Functional Regulation of Dopaminergic Neurons

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Abstract

Amygdaloid neurons are more responsive to clozapine, a dibenzodiazepine neuroleptic, than to haloperidol and other neuroleptics commonly used in the treatment of schizophrenia (Rebec and Anderson, 1986). This difference has not been observed in the neostriatum and nucleus accumbens, which like the amygdaloid complex receive dopamine input from brainstem nuclei. To determine if clozapine exerts a unique action on dopamine transmission in the amygdala, we compared the effects of acute and long-term treatment with clozapine and haloperidol on pre- and postsynaptic dopamine activity.

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References

  • Anderson, G.D. and Rebec, G.V. (in press). Clozapine and haloperidol in the amygdaloid complex: differential effects on dopamine transmission with long-term treatment. Biol. Psychiat.

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  • Rebec, G.V. and Anderson, G.D. (1986). Regional neuropharmacology of the antipsychotic drugs: implications for the dopamine hypothesis of schizophrenia. Behav. Asses., 8, 11–29.

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Author information

Authors and Affiliations

  1. Department of Psychology, Indiana University, Bloomington, IN, 47405, USA

    George V. Rebec & Glenn D. Anderson

Authors
  1. George V. Rebec
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  2. Glenn D. Anderson
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Editor information

Editors and Affiliations

  1. Clinical Pharmacology and Therapeutics Unit, Austin Hospital, University of Melbourne, Heidelberg, Australia

    P. M. Beart

  2. Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK

    G. N. Woodruff

  3. Department of Pharmacology, University of Sydney, Australia

    D. M. Jackson

Copyright information

© 1988 George V. Rebec and Glenn D. Anderson

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Rebec, G.V., Anderson, G.D. (1988). Unique Effects of Long-term Clozapine, but not Haloperidol, on Dopamine Transmission in the Amygdaloid Complex. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_40

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