Abstract
Using biochemical, electrophysiological and behavioural techniques it has been shown that dopamine (DA) D-1 and D-2 receptors are separate sites with different functions. Depending on the actual behaviour or neuronal population under study these receptors can mediate independent effects or effects which show mutual interactions (see Creese and Fraser, 1987, for reviews). In this chapter some characteristics of D-1 and D-2 agonists with different efficacies will be summarized, using stereotyped behaviour as the experimental model in rats.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andersen, P.H. and Nielsen, E.B. (1986). The dopamine D1 receptor: Biochemical and behavioural aspects. In Neurobiology of central D1-dopamine receptors. (eds. G.R. Breese and I. Creese). Plenum Press, New York and London.
Arnt, J. (1987). Behavioral studies of dopamine receptors: Evidence for regional selectivity and receptor multiplicity. In Dopamine receptors. (eds. E. Creese and C.M. Fraser). Alan R. Liss, New York.
Arnt, J. and Hyttel, J. (1986). Behavioural differentiation between effects elicited at dopamine D-1 and D-2 receptors. Clin. Neuropharmacol. 9, suppl. 4, 17–19.
Arnt, J., Hyttel, J. and Perregaard, J. (1987). Dopamine D-1 receptor agonists combined with the selective D-2 agonist quinpirole facilitate the expression of oral stereotyped behaviour in rats. Eur.J.Pharmacol. 133, 137–145.
Arnt, J. and Perregaard, J. (1987). Synergistic interaction between dopamine D-1 and D-2 receptor agonists: Circling behaviour in rats with hemitransection. Eur.J.Pharmacol. in press.
Braun, A.R. and Chase, T.N. (1986). Obligatory D-l/D-2 receptor interaction in the generation of dopamine agonist related behaviors. Eur.J.Pharmacol: 131, 301–306.
Clark, D., Hjorth, S. and Carlsson, A. (1985). Dopamine-receptor agonists: Mechanisms underlying autoreceptor selectivity. I. Review of the evidence. J.Neural Transmission 62, 1–52.
Creese, I. and Fraser, CM. (eds.) (1987). Dopamine receptors. Alan R. Liss, New York.
Hamblin, M.W. and Creese, I. (1983). Behavioral and radioligand binding evidence for irreversible dopamine receptor blockade by N-ethoxy-carbonyl-2-ethoxy-1,2-dihydroquinoline. Life Sci. 32, 2247–2255.
Hyttel, J. (1978). A comparison of the effect of neuroleptic drugs on the binding of 3H-haloperidol and 3H-cis(Z)-flupenthixol and on adenylate cyclase activity in rat striatal tissue in vitro. Prog.Neuro-Psychopharmac. 2, 329–335.
Iorio, L.C., Barnett, A., Leitz, F.H., Houser, V.P. and Korduba, C.A. (1983). SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems. J.Pharmacol.Exp.Ther. 226, 462–468.
Meller, E., Bohmaker, K., Goldstein, M. and Friedhoff, A.J. (1985). Inactivation of D1 and D2 dopamine receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vivo: Selective protection by neuroleptics. J.Pharmacol.Exp.Ther. 233, 656–662.
Meller, E., Bohmaker, K., Namba, Y., Friedhoff, A.B. and Goldstein, M. (1987). Relationship between receptor occupancy and response at striatal dopamine autoreceptors. Molec.Pharmacol. 31, 592–598.
Rosengarten, H., Schweitzer, J.W. and Friedhoff, A.J. (1986). Selective dopamine D2 receptor reduction enhances a D1 mediated oral dyskinesia in rats. Life Sci. 39, 29–35.
Weinstock, J., Hieble, J.P. and Wilson, J.W., III (1985). The chemistry and pharmacology of 3-benzazepine derivatives. Drugs of the future 10, 645–697.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1988 Jørn Arnt, Klaus Peter Bøgesø and John Hyttel
About this chapter
Cite this chapter
Arnt, J., Bøgesø, K.P., Hyttel, J. (1988). Dopamine D-1 and D-2 Receptor Differentiation Revealed by Behavioural Studies in Rats. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_17
Download citation
DOI: https://doi.org/10.1007/978-1-349-10047-7_17
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-10049-1
Online ISBN: 978-1-349-10047-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)