Abstract
Up till 1983, 4 years after the introduction of the D-1/D-2 dopamine receptor classification (Kebabian and Calne, 1979), there was still said to be no function for the D-1 receptor. Most of the drugs used in the treatment of psychosis or Parkinsonian patients were supposed to act by blocking or stimulating D-2 receptors. However the development of selective drugs for the D-1 receptor, like SCH 23390 (Iorio et al., 1983), has given us some insight in the role of the D-1 receptor in biochemical and physiological processes. Now it is generally accepted that the D-1 receptor is a real outer membrane receptor: it binds D-1 selective drugs like SKF 38393 and SCH 23390 both in vivo and in vitro; it increases cyclic AMP (Kebabian and Calne, 1979) and DARPP-32 formation upon stimulation (Hemmings et al., 1987); it interacts with opiate or muscarinic receptors in the CNS in transducing signals to intracellular processes (Kelly and Nahorski, 1986; Schoffelmeer et al., 1986).
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© 1988 J.C. Stoof
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Stoof, J.C. (1988). Biochemical Insights into the D-1/D-2 Receptor Interactions. In: Beart, P.M., Woodruff, G.N., Jackson, D.M. (eds) Pharmacology and Functional Regulation of Dopaminergic Neurons. Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-10047-7_16
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DOI: https://doi.org/10.1007/978-1-349-10047-7_16
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