Abstract
The production and uses of monoclonal antibodies constitute a major revolution in science, as witnessed by the large number of laboratories now engaged in this type of work. It is only with the benefit of hindsight that the full implications of the development of fusion techniques to obtain cell lines can be realised, i.e. the fusion of a cell type having the characteristic of immortality or the ability to grow and divide continuously provided it is given the correct environment, with a cell having the required secretory capacity to give a hybrid cell which has the twin characteristics of immortality while secreting a product of interest. This was first achieved satisfactorily in 1975 by Köhler and Milstein when antibodies (monoclonal antibodies) were first produced by such technology.
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© 1988 Bioengineering Unit, University of Strathclyde
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Stimson, W.H., MacDonald, C. (1988). Monoclonal Antibodies and the use of Recombinant DNA Technology in the Production of Immortalised Animal Cells. In: Paul, J.P., McCruden, A.B., Schuetz, P.W. (eds) The Influence of New Technology on Medical Practice. Keynes Seminars. Palgrave, London. https://doi.org/10.1007/978-1-349-09609-1_29
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DOI: https://doi.org/10.1007/978-1-349-09609-1_29
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