Molecular Interactions of Antidepressants with the Serotonergic Receptor 5-HT1D Coupled to a High-affinity Adenylate Cyclase Activity: Importance of the Site Labelled by [3H]-Minaprine
Several neurochemical theories of major affective disorders have been presented during the last decades. Initially, the fact that patients treated with reserpine developed symptoms which resemble certain forms of depression suggested that biogenic amines may play an important role in the disease (Freis, 1954; Achor et al., 1955; Muller et al., 1955; Lemieux et al., 1956). It is known that reserpine depletes brain tissues not only in dopamine and in noradrenaline but also in serotonin (5-hydroxytryptamine, 5-HT) (Pletscher et al., 1956); therefore the hypothesis has been proposed that depression might be related to a deficit in those amines, and, in particular, may involve 5-HT metabolite disturbances (Coppen, 1967; Murphy et al., 1978; van Praag, 1982). However, Crow et al. (1984) did not observe any changes in serotonin metabolites in individuals committing suicide.
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