Advertisement

Molecular Interactions of Antidepressants with the Serotonergic Receptor 5-HT1D Coupled to a High-affinity Adenylate Cyclase Activity: Importance of the Site Labelled by [3H]-Minaprine

  • G. Fillion
  • S. Dufois
  • C. Fayolle
  • M. P. Fillion
  • P. Oudar
  • P. Barone
Chapter

Abstract

Several neurochemical theories of major affective disorders have been presented during the last decades. Initially, the fact that patients treated with reserpine developed symptoms which resemble certain forms of depression suggested that biogenic amines may play an important role in the disease (Freis, 1954; Achor et al., 1955; Muller et al., 1955; Lemieux et al., 1956). It is known that reserpine depletes brain tissues not only in dopamine and in noradrenaline but also in serotonin (5-hydroxytryptamine, 5-HT) (Pletscher et al., 1956); therefore the hypothesis has been proposed that depression might be related to a deficit in those amines, and, in particular, may involve 5-HT metabolite disturbances (Coppen, 1967; Murphy et al., 1978; van Praag, 1982). However, Crow et al. (1984) did not observe any changes in serotonin metabolites in individuals committing suicide.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Achor, R.WP., Hanson, N.O., and Grifford, R.W. (1955). Hypertension treated with Rauwolfia serpentina (whole root) and with reserpine. J. Am. Med. Ass., 159, 841–5.CrossRefGoogle Scholar
  2. Aprison, M.W., and Hintgen, J.N. (1981). Hypersensitive serotonergic receptors: a new hypothesis for one subgroup of unipolar depression derived from an animal model. In Haber, B., Gabay, S., Issidorides, D.R., and Alivisator, S. (eds.), Serotonin: Current Aspect of Neurochemistry and Function, Plenum, New York, 627–55.Google Scholar
  3. Banerjee, S.P., Kuhn, L.S., Riggi, S.J., and Chander, S.K. (1977). Development of beta-adrenergic receptor subsensitivity by antidepressants. Nature, 268, 455–6.CrossRefPubMedGoogle Scholar
  4. Bennett J.P., and Snyder, S.H. (1976). Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors. Mol. Pharmacol, 12, 373–89.PubMedGoogle Scholar
  5. Bizière, K., Worms, P., Kan, J.P., Mandel, P., Garattini, S., and Roncucci, R. (1985). Minaprine, a new drug with antidepressant properties. Drugs Exp. Clin. Res., 11, 831–40.PubMedGoogle Scholar
  6. Bohacek, N., Ravie, M., and Bizière, K. (1986). A double-blind comparison of minaprine and imipramine in the treatment of depressed patients. J. Clin. Psychopharmacol., 6, 320–1.PubMedGoogle Scholar
  7. Bradley, P.B., Engel, G., Feniuk, W., Fozard, J.R., Humphrey, P.P.A., Middlemiss, D.N., Mylecharane, E.J., Richardson, B.P., and Saxena, P.R. (1986). Proposals for the clarification and nomenclature of functional receptors for 5-HT. Nueropharmacol., 25, 563–76.CrossRefGoogle Scholar
  8. Charney, D.S., Menkes, D.B., and Heninger, G.R. (1981). Receptor sensitivity and the mechanism of action of antidepressant treatment. Archs gen. Psychiat., 38, 1160–5.CrossRefGoogle Scholar
  9. Coppen, A.J. (1967). The biochemistry of affective disorders. Br. J. Psychiat., 113, 1407–11.CrossRefGoogle Scholar
  10. Crow, T.J., Cross, A.J., Cooper, S.J., Deakin, J.F.W., Ferrier, I.N., Johnson, J.A., Joseph, M.H., Owen, F., Poulter, M., Lofthouse, R., Corsellis, J.A.N., Chambers, D.R., Blessed, G., Perry, E.K., Perry, R.H., and Tomlinson, B.E. (1984). Neurotransmitter receptors and monoamine metabolites in the brains of patients with alzheimer-type dementia and depression, and suicides. Neuropharmacol., 23, 1561–9.CrossRefGoogle Scholar
  11. Fillion, G., Fillion, M.P., Spirakis, C, Bahers, J.M., and Jacob, J. (1976). 5-hydroxytrypt-amine binding to synaptic membranes from rat brain. Life Sci., 18, 65–74.CrossRefPubMedGoogle Scholar
  12. Fillion, G., Beaudoin, D., Rousselle, J.C, Deniau, J.M., Fillion, M.P., Dray, F., and Jacob, J. (1979). Decrease of [3H]-5-HT high affinity binding and 5-HT adenylate cyclase activation after kainic acid lesion in rats brain striatum. J. Neurochem., 33, 567–70.CrossRefPubMedGoogle Scholar
  13. Fillion, G., and Fillion, M.P. (1981). Modulation of affinity of postsynaptic serotonin receptors by antidepressant drugs. Nature, 292, 349–51.CrossRefPubMedGoogle Scholar
  14. Freis, E. (1954). Mental depression in hypertensive patients treated for long periods with large doses of reserpine. New Eng. J. Med., 251, 1006–8.CrossRefPubMedGoogle Scholar
  15. Fuxe, K., Ogren, S.O., Agnati, L.F., Benfenati, F., Fredholm, B., Andersson, K., Zini, I., and Eneroth, P. (1983). Chronic antidepressant treatment and central 5-HT synapses. Neuropharmacol., 22, 389–400.CrossRefGoogle Scholar
  16. Garcha, G., Smokcum, R.W.J., Stephenson, J.D., and Weeramantri, T.B. (1985). Effects of some atypical antidepressants of beta-adrenoreceptors binding and adenylate cyclase activation in the rat forebrain. Eur. J. Pharmacol., 108, 1–7.CrossRefPubMedGoogle Scholar
  17. Gillet, G., Ammor, S., and Fillion, G. (1985). Serotonin inhibits acetylcholine release from rat striatum slices: Evidence for a presynaptic receptor mediated effect. J. Neurochem., 45, 1687–91.CrossRefPubMedGoogle Scholar
  18. Hamon, M., Bourgoin, S., Gozlan, H., Hall, M.D., Goetz, C, Artaud, F., and Horn, A-S. (1984). Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(Di-n-Propyl-amino)tetralin) in the rat brain. Eur. J. Pharmac., 100, 263–76.CrossRefGoogle Scholar
  19. Jouvent, R., Lancrenon, S., Patay, M., and Widlocher, D.A. (1984). A controlled study: minaprine versus placebo in inhibited depressed out-patients. In Recent Advances in Psychiatric Treatment. First European Conference. Vienna.Google Scholar
  20. Kellar, K.J., Cascio, C.S., Butler, J.A., and Kurtzke, R.N. (1981). Differential effects of electroconvulsive shock and antidepressant drugs on serotonin2 receptors in rat brain. Eur. J. Pharmacol., 69, 515–18.CrossRefPubMedGoogle Scholar
  21. Lemieux, G., Davignon, A., and Genest, J. (1956). Depressive states during rauwolfia therapy for arterial hypertension. A report of 30 cases. Can. Med. Ass. J., 74, 522–26.PubMedPubMedCentralGoogle Scholar
  22. Lowry O.H., Rosebrough, N.S., Farr, A.L., and Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265–75.PubMedGoogle Scholar
  23. Maggi, A., U’Prichard, D.C, and Enna, S.J. (1980). Differential effects of antidepressant treatment on brain monoaminergic receptors. Eur. J. Pharmacol., 61, 91–8.CrossRefPubMedGoogle Scholar
  24. Maura, G., and Raiteri, M. (1986). Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release. Eur. J. Pharmacol., 129, 333–7.CrossRefPubMedGoogle Scholar
  25. Mishra, R., Janowsky, A., and Sulser, F. (1980). Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: subsensitivity without reduction in beta-adrenergic receptor binding. Neuropharmacol., 19, 983–7.CrossRefGoogle Scholar
  26. Muller, L. Pryor, W.W., Gibbons, J.E., and Orgain, E.S. (1955). Depression and anxiety occurring during rauwolfia therapy. J. Am. Med. Ass., 159, 836–9.CrossRefGoogle Scholar
  27. Murphy, D.L., Camphell, I., and Costa, J.L. (1978). Current status of the indoleamine hypothesis of the affective disorders. In Lipton, M.A., Dimascio, A., andKillam, K.F. (eds.), Psychopharmacology: A Generation of Progress. Raven, New York, 1235–47.Google Scholar
  28. Ogren, S.O., Fuxe, K., Agnati, L.F., Gustafsson, J.A., Jonsson, G., and Holm, A.C. (1979). Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems for antidepressant drugs. J. Neurol. Trans., 46, 85–103.CrossRefGoogle Scholar
  29. Peroutka, S.J., and Snyder, S.H. (1980). Regulation of serotonin 5-HT2 receptors labelled with [3H]-spiroperidol by chronic treatment with the antidepressant amitriptyline. J. Pharmacol Exp. Ther., 215, 582–7.PubMedGoogle Scholar
  30. Pletscher, A., Shore, P.A., and Brodie, B.B. (1956). Serotonin as a mediator of reserpine action in the brain. J. Pharmacol., 116, 84–9.Google Scholar
  31. Radmayr, K, Bizière, K., Bentel, U. (1986). Minaprine and maprotiline in endogenous depression. A double-blind controlled study. Clin. Trials J., 23, 100–9.Google Scholar
  32. Robaut, C, Fillion, M.P., Dufois, S., Fayolle-Bauguen, C, Rousselle, J.C, Gillet, G., Benkirane, S., and Fillion, G. (1985). Multiple high affinity binding sites for 5-hydroxy-tryptamine: a new class of sites distinct from 5-HT1 and S2. Brain Res., 346, 250–62.CrossRefPubMedGoogle Scholar
  33. Schildkraut, J.J., Schamberg, S.M., Breese, G.R., and Kopin, I.J. (1967). Norepinephrine metabolism and drugs used in the affective disorders: a possible mechanism of action. Am. J. Psychiatry, 124, 600–5.CrossRefPubMedGoogle Scholar
  34. Segawa, T., Mizuta, T., and Nomura, Y. (1979). Modification of central 5-hydroxytrypt-amine binding sites in synaptic membranes from rat brain after long-term adminstration of tricyclic antidepressants. Eur. J. Pharmacol., 58, 75–83.CrossRefPubMedGoogle Scholar
  35. Sugrue, M.F. (1983). Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning. Pharmacology and Therapeutics, 21, 1–33.CrossRefPubMedGoogle Scholar
  36. Sulser, F., Vetulani, J., and Mobley (1978). Mode of action of antidepressant drugs. Bio-chem. Pharmacol, 27, 257–61.CrossRefGoogle Scholar
  37. Van Praag, H.M. (1982). Neurotransmitters and CNS disease: depression. Lancet, ii, 1264–7.Google Scholar
  38. Vizi, E.S., Harsing, G., and Zsilia, G. (1981). Evidence of the modulatory role of serotonin in acetylcholine release from striatal interneurons. Brain Research, 212, 89–9.CrossRefPubMedGoogle Scholar
  39. Wander T.J., Nelson, A., Haruo, O., and Richelson, E. (1986). Antagonism by antidepressants of serotonin S1 and S2 receptors of normal human brain in vitro. Eur. J. Pharmacol, 132, 115–21.CrossRefPubMedGoogle Scholar
  40. Whitaker-Azmitia, P., and Azmitia, E.C. (1986). [3H]-5-hydroxytryptamine binding to brain astroglial cells: differences between intact and homogenized preparation and mature and immature cultures. J. Neurochem., 46, 1186–89.CrossRefPubMedGoogle Scholar
  41. Worms, P., Kan, J.P., Perio, A., Wermuth, G.G., Bizière, K., and Roncucci, R. (1986). Profil pharmacologique d’un psychotrope original, la minaprine: comparaison avec six antidépresseurs de référence. J. Pharmacol. (Paris), 17, 126–38.PubMedGoogle Scholar

Copyright information

© The Editors and the Contributors 1988

Authors and Affiliations

  • G. Fillion
  • S. Dufois
  • C. Fayolle
  • M. P. Fillion
  • P. Oudar
  • P. Barone

There are no affiliations available

Personalised recommendations