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The Vascular (DA1) Dopamine Receptor

  • Jai D. Kohli
  • Leon I. Goldberg
Chapter
Part of the Satellite Symposia of the IUPHAR 10th International Congress of Pharmacology book series

Abstract

Investigation of the unusual cardiovascular effects of DA by Goldberg and colleagues in the 1960s led to the hypothesis of a specific DA receptor which mediated vasodilatation in the renal and mesenteric vascular beds of the dog (Goldberg, 1972). In the 1970s the action of drugs on the postganglionic sympathetic nerves modulating the release of the transmitter via the presynaptic receptors was discovered (Langer, 1977, 1980; Starke, 1977). In the course of the investigation of presynaptic alpha-adrenoceptors, Langer (1973) and McCulloch et al. (1973) obtained evidence for the presence of specific DA receptors on sympathetic nerve terminals.

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© Jai D. Kohli and Leon I. Goldberg 1988

Authors and Affiliations

  • Jai D. Kohli
  • Leon I. Goldberg

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