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GABA Receptors, Depression and Antidepressant Drug Action

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Receptor-Receptor Interactions

Part of the book series: Wenner-Gren Center International Symposium Series ((WGS))

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Abstract

The clinical demonstration of the major antidepressant action of GABAmimetic agents (Morselli et al., 1980; 1986; Muscn, 1986; Weiss et al., 1986) has led to the formulation of a coherent GABA hypothesis of depression. This hypothesis in addition is supported by a large body of evidence which however, remained inconclusive in the absence of clear cut clinical data with GABAmimetics. The compounds which have stimulated this progress include two benzylidene GABAmimetics, progabide: 4- [(4-chlorophenyl) (5-fluoro-2-hydroxy-phenyl)-methylene]amino butanamide, and fengabine: 2-[(Butylimino) (2-chlorophenyl)methyl]-4-chlorophenyl.

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Authors
  1. Giuseppe Bartholini
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  2. Kenneth G. Lloyd
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  3. Bernard Scatton
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  4. Branimir Zivkovic
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  5. Paolo L. Morselli
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Editor information

Editors and Affiliations

  1. Department of Histology, Karolinska Institutet, Stockholm, Sweden

    Kjell Fuxe

  2. Department of Human Physiology, University of Modena, Modena, Italy

    Luigi F. Agnati

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© 1987 The Wenner-Gren Center

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Bartholini, G., Lloyd, K.G., Scatton, B., Zivkovic, B., Morselli, P.L. (1987). GABA Receptors, Depression and Antidepressant Drug Action. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08949-9_35

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