Abstract
Recent studies on the mechanism of action of antidepressant drugs have focussed on alterations in monoaminergic neurons following prolonged drug administration, since only those effects elicited after long term antidepressant treatment might be the biochemical substrate accounting for the delayed onset of therapeutic activity (Racagni and Brunello, 1984). Chronic antidepressant administration is associated with several adaptive changes in central monoaminergic systems, which can occur both pre- and postsynaptically (Sugrue, 1983). One of the most significant and constant effect shared by all the treatments that are known to relieve depression, including electroconvulsive therapy, is the down-regulation of beta adrenergic receptors (Banerjee et al., 1977) coupled to the desensitization of noradrenaline (NE) dependent adenylate cyclase (Vetulani and Sulser, 1975). Moreover among the possible mechanisms responsible for the adaptation of central aminergic neurons following antidepressant administration, the interaction between serotonergic and noradrenergic system and changes in the chemico-physical properties of the membranes should be considered.
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References
Banerjee, S.P., Kung, L.S., Riggi, S.J., and Chande, S.K. (1977). Development of beta-adrenergic receptor subsensitivity by antide-pressants. Nature (Lond.), 268, 455–456.
Berridge, M.J., Downes, C.P., and Hanley, M.R. (1982). Lithium amplifies agonist dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J., 206, 587–595.
Brunello, N., Barbaccia, M.L., Chuang, D.M., and Costa, E. (1982). Down regulation of beta-adrenergic receptors following repeated desimipramine injections; permissive role of serotonergic axons. Neuropharmacology, 21, 1145–1149.
Brunello, N., Mocchetti, I., Volterra, A., Cuomo, V., and Racagni, G. (1985a). Serotonergic modulation of cortical rat noradrenergic system in the mechanism of action of antidepressant drugs. Psychopharm. Bull., 21, 379–384.
Brunello, N., Volterra, A., Cagiano, R., Ianieri, G.C., Cuomo, V., and Racagni, G. (1985b). Biochemical and behavioural changes after prolonged treatment with desimipramine: interaction with p-chloro-phenylalanine. Naunyn-Schrniedeberg’s Arch. Pharmacol., 331, 20–22.
Bylund, D.B., and Snyder, S.H. (1976). Beta-adrenergic receptor binding in membrane preparations from mammalian brain. Mol. Pharmacol., 12, 568–580.
Habert, E., Graham, D., Tahraoui, L., Claustre, Y., Langer, S.Z. (1985). Characterization of 3H-paroxetine binding to rat cortical membranes. Eur. J. Pharmacol., 118, 107–114.
Hirata, F., and Axelrod, J., (1980). Phospholipid methylation and the transmission of biological signals through membranes. Sciences, 209, 1082–1090.
Janowsky, A., Okada, F., Manier, D.H., Steranka, L., and Sulser, F. (1982). Role of serotonergic input in the regulation of the beta-adrenoceptor coupled adenylate cyclase system. Science, 218, 900–901.
Leysen, J.E., Niemegeers, C.J.E., Van Nueten, J.M., and Laduron, P.M. (1982). 3H-Ketanserin (R 41468), a selective 3H-ligand for serotonin-2 receptor binding sites: binding properties, brain distribution and functional role. Mol. Pharmacol., 21, 301–314.
Racagni, G., Mocchetti, I., Calderini, G., Battistella A., and Brunello, N., (1983). Temporal sequence of changes in central noradrenergic system of rat after prolonged antidepressant treatment: receptor desensitization and neurotransmitter interactions. Neuropharmacology, 22, 415–424.
Racagni, G., and Brunello, N. (1984). Transynaptic mechanisms in the action of antidepressant drugs. Trends Pharmacol. Sci., 5, 527–531.
Racagni, G., Brunello, N., Mocchetti, I., Cagiano, R., and Cuomo, V. (1985). Presynaptic and transynaptic mechanisms involved in the subsensitivity of rat cortical noradrenergic system after long-term antidepressant treatment. Acta Pharmacol. and Toxicol., 56 (Suppl. 1), 190–197.
Raisman, R., Briley, M., and Langer, S.Z. (1980). Specific tricyclic antidepressant binding sites in rat brain characterized by high affinity H-imipramine binding. Eur. J. Pharmacol., 61, 373–380.
Sugrue, M. (1983). Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning. Pharmac. Ther., 21, 1–33.
Sulser, F., Vetulani, J., and Mobley, P.L. (1978). Mode of action of antidepressant drugs. Biochem. Pharmacol., 27, 257–261.
Vetulani, J., and Sulser, F. (1975). Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic-AMP generating system in limbic forebrain. Nature, 257, 495–496.
Wolfe, B.B., Harden, T.K., Sporn, J.R., and Molinoff, P.B. (1978). Presynaptic modulation of beta-adrenergic receptors in rat cerebral cortex after treatment with antidepressant. J. Pharmacol. Exp. Ther., 207, 446–457.
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© 1987 The Wenner-Gren Center
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Brunello, N. et al. (1987). Receptor Interactions in Antidepressant Neurochemical Mechanisms: Modulation by Membrane Components. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08949-9_32
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DOI: https://doi.org/10.1007/978-1-349-08949-9_32
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