Abstract
The morphological organization of monoamine systems in brain and psychopharmacological studies have long suggested a functional linkage between noradrenergic and serotonergic neuronal systems. Recent studies of the molecular mechanism of action of antidepressants have added additional support for an aminergic interaction in the central nervous system (CNS). In the present manuscript, we will review this evidence and evaluate the possible molecular basis for the adrenergic/serotonergic link.
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References
Anderson, J.L. (1983). Serotonin receptor changes after chronic antidepressant treatments: Ligand binding, electrophysiological and behavioral studies. Life Sci. 32, 1791–1801.
Batty, I.R., Nahorski, S.R. and Irvine, R.F. (1985). Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices. Biochem. J. 232, 211–215.
Berridge, M.J. (1985). The molecular basis of communication within cells. Scientific Amer. 253, 142–152.
Brunello, N., Volterra, A., Cagiano, R., Ianieri, G.C., Cuomo, V. and Racagni, G. (1985). Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine. Naunyn-Schmiedeberg’s Arch. Pharmacol. 331, 20–22.
Conn, P.J. and Sanders-Bush, E. (1984). Selective 5HT-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex. Neuropharmacology 23, 993–996.
Conn, P.J. and Sanders-Bush, E. (1985). Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions. J. Pharmacol. Exp. Ther. 234, 195– 203.
Conn, P.J. and Sanders-Bush, E. (1986a). Regulation of serotonin-stimulated phosphoinositide hydrolysis: Relation to the serotonin 5HT-2 binding site. J. Neurosci. in press.
Conn, P.J. and Sanders-Bush, E. (1986b). Agonist-induced phosphoinositide hydrolysis in choroid plexus. J. Neurochem. in press.
Conn, P.J., Sanders-Bush, E., Hoffman, B.J. and Hartig, P.R. (1986a). A unique serotonin receptor in choroid plexus is linked to phosphoinositide hydrolysis. Proc. Nat. Acad. Sci. USA 83, 4086–4088.
Conn, P.J., Janowsky, A. and Sanders-Bush, E. (1986b). Denervation supersensitivity of 5-HT-lc receptors in rat choroid plexus. Brain Res. in press.
de Chaffoy de Courcelles, D., Leysen, J.E., De Clerck, F., Van Belle, H. and Janssen, P.A.J. (1985). Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites. J. Biol. Chem. 260, 7603–7608.
Dixon, J.F. and Hokin, L.E. (1985). The formation of inositol-1,2-cyclic phosphate on agonist stimulation of phosphoinositide breakdown in mouse pancreatic minilobules. J. Biol. Chem. 260, 16068–16071.
Irvine, R.F., Letcher, A.J., Lander, D.J. and Downes, C.P. (1984), Inositol trisphosphates in carbachol-stimulated rat parotid glands. Biochem. J. 223, 237–243.
Janowsky, A., Labarca, R. and Paul, S.M. (1984). Characterization of neurotransmitter receptor-mediated phosphatidylinositol hydrolysis in the rat hippocampus. Life Sci. 35, 1953–1961.
Janowsky, A.J., Steranka, L.R., Gillespie, D.D. and Sulser, F. (1982). Role of neuronal signal input in the down-regulation of central noradrenergic receptor function by antidepressant drugs. J. Neurochem. 39, 290–292.
Kendall, D.A. and Nahorski, S.R. (1985). 5-hydroxytryptamine-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: Pharmacological characterization and effects of antidepressants. J. Pharmacol. Exp. Therap. 233, 473–479.
Kent, R.S., DeLean, A. and Lefkowitz, R.J. (1980). A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by ligand binding data. Mol. Pharmacol. 17, 14–23.
Manier, D.H., Gillespie, D.D., Steranka, L.R. and Sulser, F. (1984). A pivotal role for serotonin in the down-regulation of beta-adrenoceptors by antidepressants: Reversibility of the action of p-chlorophenylalanine by 5-hydroxytryptophan. Experientia 40, 1223–1226.
Manier, D.H., Gillespie, D.D., Sanders-Bush, E. and Sulser, F. (1986). The serotonin/noradrenaline-link in brain: I. The role of noradrenaline and serotonin in the regulation of density and function of beta adrenoceptors and its alteration by desipramine. Naunyn-Schmiedeberg’s Arch. Pharmacol. submitted.
Moskowitz, M.A., Liebman, J.F., Reinhard, Jr., J.F. and Schlosberg, A. (1979). Raphe origin of serotonin-containing neurons within choroid plexus of the rat. Brain Res. 169, 590–594.
Nakamura, S. and Mariyasu, N. (1978). Nerve fibers and nerve endings in the choroid plexus: electron microscopic study. Brain and Nerve 30, 259–266.
Napoleone, P., Sancesario, B. and Amenta, F. (1982). Indoleaminergic innervation of rat choroid plexus: a fluorescence histochemical study. Neurosci. Lett. 34, 143–147.
Nathanson, J.A. (1979). Beta-adrenergic-sensitive adenylate cyclase in secretory cells of choroid plexus. Science 204, 843–844.
Nimgaonkar, V.L., Goodwin, G.M., Davies, C.L. and Green, A.R. (1985). Down-regulation of beta-adrenoceptors in rat cortex by repeated administration of desipramine electronconvulsine shock and clenbuterol requires 5HT neurons but not 5HT. Neuropharmacology 24, 279–283.
Hirasawa, K. and Nishizuka, Y. (1985). Phosphatidylinositol turnover in receptor mechanism and signal transduction. Ann. Rev. Pharmacol. Toxicol. 25, 147–170.
Pazos, A., Hayer, D. and Palacios, J.M. (1984). The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site. Europ. J. Pharmacol. 106, 539–546.
Roth, B.L., Nakaki, T., Chuang, D. and Costa, E. (1986). 5-Hydroxytryptamine-2 receptors coupled to phospholipase C in rat aorta: Modulation of phosphoinositide turnover by phorbol ester. J. Pharmacol. Exp. Ther. 238, 480.
Sanders-Bush, E. and Conn, P.J. Neurochemistry of serotonin neuronal systems: Consequences of serotonin receptor activation. In Psychopharmacology, The Third Generation of Progress, in press, 1986.
Sibley, D.R., Nambi, P., Peters, J.R. and Lefkowitz, R.J. (1984). Phorbol diesters promote beta-adrenergic receptor phosphorylation and adenylate cyclase densitization in duck erythrocytes. Biochem. Biophys. Res. Comm. 121, 973–979.
Stockmeier, C.A., Martino, A., and Kellar, K.J. (1985). A strong influence of serotonin axons on beta-adrenergic receptors in rat brain. Science 230, 323–325.
Sulser, F., Janowsky, A.J., Okada, F., Manier, D.H. and Mobley, P.L. (1983). Regulation of recognition and action function of the norepinephrine receptor-coupled adenylate cyclase system in brain: Implications for the therapy of depression. Neuropharmacology 22, 425–431.
Sulser, F. (1985). The serotonin-noradrenaline link hypothesis of affective disorders. In Psychiatry, Vol. 2, (eds. P. Pichot, P. Berner, R. Wolf, and K. Thau). Plenum Publishing Corp., New York, N.Y., 411–416.
Wilson, D.B., Connolly, T.M., Bross, T.E., Majerus, P.W., Serman, W.R., Tyler, A.N., Rubin, L.J. and Brown, J.E. (1985). Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C: physiological effects in limulus photoreceptors. J. Biol. Chem. 260, 13496–13501.
Yagaloff, K.A. and Hartig, P.R. (1985). 125I-Lysergic acid diethylamide binds to a novel sertonergic site on rat choroid plexus epithelial cells. J. Neurosci. 5, 3178–3183.
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Sanders-Bush, E., Sulser, F. (1987). Serotonin/Norepinephrine Receptor Interactions: Sensitivity Changes after Antidepressants and Lesions. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-08949-9_31
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DOI: https://doi.org/10.1007/978-1-349-08949-9_31
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