Adenosine Triphosphate: ‘Pre-transmitter’, Co-transmitter or Modulator at the Skeletal Muscle?
Burnstock (1982) has summarized evidence suggesting that adenosine triphosphate (ATP) acts as a co-transmitter or neuromodulator in a variety of tissues. This paper concerns ATP and the neuromuscular junction of skeletal muscle and also the embryonic muscle cell, represented by cultured myotubps.
KeywordsSynaptic Vesicle Neuromuscular Junction Transmitter Release Electric Organ Inositol Triphosphate
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- Berridge, M.J. & Irvine, R.F. (1984) Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature, 312, 315– 321.Google Scholar
- Burnstock, G. & Kennedy, C. (1985) Is there a basis for distingguishing two types of P2-purinoceptor? Gen. Pharmac., 16, 433–440.Google Scholar
- Desmedt, J.E. (1978) Muscular dystrophy contrasted with denervation: different mechanisms underlying spontaneous fibrillations. In Contemporary clinical neurophysiology. (eds. WA Cobb & H Van Duijm). Elsevier, Amsterdam.Google Scholar
- Eusebi, F., Molinaro, M. & Zani, B.M. (1985) Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes. J. Cell. Biol., 100, 339–1343.Google Scholar
- Gilliat, R.W. & Westgaard, R.H. (1978) Nerve-muscle interactions. In Contemporary clinical neurophysiology. (eds. WA Cobb & H Van Duijm) Elsevier, Amsterdam.Google Scholar
- Häggblad, J. (1986) Neuromuscular junction revisited: Biochemical studies on mechanisms involved in transmission events. Doctoral dissertation, manuscript. University of Stockholm, Sweden.Google Scholar
- Häggblad, J. & Heilbronn, E. (1986) Externally applied ATP causes inositol triphosphate accumulation in cultured chick myotubes. Neurosci Lett., in press.Google Scholar
- Häggblad, J., Eriksson, H., Hedlund, B. & Heilbronn, E. (1986) Forskolin blocks agonist mediated permeability of chick myotube nicotinic receptors and inhibits binding of 3H-phencyclidine to Torpedo microsac nicotinic receptors. Naunyn Schm. Arch. Pharmac., submitted.Google Scholar
- Häggblad, J., Eriksson, H., & Heilbronn, E. (1985b) Effects of extracellular ATP on 86Rb-influx in chick myotubes: Indications of a cotransmitter role in neuromuscular transmission. In Molecular basis of nerve activity.(eds. J-P Changeux, F Hucho, A Maelicke & E Neumann) Walter de Gruyter, Berlin, New York.Google Scholar
- Heilbronn, E. & Häggblad, J. (1986) A case for ATP as a neurotransmitter and trigger of postsynaptic Ca-release at the neuromuscular junction? In Cellular and molecular basis of cholinergic funtion. (ed. M J Dowdal1 ), in press.Google Scholar
- Kuffler, S.W. & Nicholls, J.G. (1976) From neurone to brain. Sinauer Ass. Inc., Sunderland, MA, USA.Google Scholar
- Lømo, T. (1976) The role of activity in the control of membrane and contractile properties of skeletal muscle. In Motor innervation of muscle.(ed. S Thesleff). Academic Press, London.Google Scholar
- Meunier, F.M. & Morel, N. (1978) Adenosine uptake by cholinergic synaptosomes from Torpedo electric organ. J. Neurochem., 31, 845– 851.Google Scholar
- Miyamoto, M.D. & Breckenridge, B. Mc L. (1974) A cyclic adenosine monophosphate link in the catecholamine enhancement of transmitter release at the neuromuscular junction. J. Gen. Physiol., 63, 609– 624.Google Scholar
- Nemeth, P.M. (1982) Electrical stimulation of denervated muscle prevents decreases in oxidative enzymes. Muscle & Nerve, 5,134–139.Google Scholar
- Ribeiro, J.A. & Dominguez, M.L. (1978) Mechanisms of depression of neuromuscular transmission by ATP and adenosine. J. Physiol. (Paris), 74, 491–496.Google Scholar
- Tashiro, T. & Stadtler, H. (1978) Chemical compositions of cholinergic synaptic vesicles from Torpedo marmorata based on improved purification. Eur. J. Biochem., 90, 479–487.Google Scholar
- Volpe, P., DiVirgilio, F., Pozzan, T. & Salviati, G. (1986) Role of inositol 1,4,5-trisphosphate in excitation-contraction coupling in skeletal muscle, FEBS Lett., 197, 1–4.Google Scholar
- Zimmermann, H. & Whittaker, V.P. (1974) Effect of electrical stimulation on the yield and composition of synaptic vesicles from cholinergic synapses of the electric organ of Torpedo: a combined biochemical, electrophysiological and morphological study. J. Neurochem., 22,435–450.Google Scholar