On the Role of Receptor-Receptor Interactions in Synaptic Transmission: Biochemical and Autoradiographical Studies on the Interactions between α2-adrenergic and Neuropeptide Y Receptors in the Nucleus Tractus Solitarius

  • Kjell Fuxe
  • Luigi F. Agnati
  • Anders Härfstrand
  • Bertil B. Fredholm
  • Madhu Kalia
  • Menek Goldstein
Part of the Wenner-Gren Center International Symposium Series book series (WGS)


In 1980 we postulated that receptors can modulate the binding characteristics of oneanother in membrane preparations under equilibrium conditions, and we introduced the concept of receptor-receptor interaction, an event which may represent an important intramembrane integrative mechanism in synaptic transmission (see Agnati et al., 1983a, b, c, d, 1986, Fuxe and Agnati 1985, Fuxe et al., 1981, 1983, 1984a, b, 1986). In the present paper we will present our recent work on the interactions between neuropeptide Y (NPY) and α2-adrenergic receptors in the nucleus tractus solitarius (NTS) using biochemical binding techniques and quantitative receptor autoradiography.


Medulla Oblongata Nucleus Tractus Solitarius Area Postrema Dorsal Motor Nucleus Agonist Binding Site 
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© The Wenner-Gren Center 1987

Authors and Affiliations

  • Kjell Fuxe
  • Luigi F. Agnati
  • Anders Härfstrand
  • Bertil B. Fredholm
  • Madhu Kalia
  • Menek Goldstein

There are no affiliations available

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