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Serotonin Neurones and Receptors in Alzheimer’s Disease

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Book cover New Concepts in Alzheimer’s Disease

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Abstract

Recent research into the senile and presenile dementias (collectively termed Alzheimer’s disease) has concentrated on deficits in the cholinergic system (see, for example, Perry and Perry, 1980; Rossor, 1982; Sims and Bowen, 1983), and there is much circumstantial and direct evidence to link the cholinergic deficit with the cognitive deterioration seen in this disease (Perry et al., 1978; Drachman, 1981; Francis et al., 1985). Nevertheless, there are selective deficits in other neurotransmitter pathways in Alzheimer’s disease and, in particular, losses of somatostatin-containing cells and ascending aminergic pathways have been reported (for a recent review see Hardy et al., 1985). The relationship of these changes in non-cholinergic neurones to the cognitive and behavioural deterioration seen in Alzheimer’s disease is not yet understood but it would be surprising if the changes seen in aminergic pathways were not in some way related to aspects of the personality changes manifested in this disease (Semple et al., 1982).

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Authors
  1. D. N. Middlemiss
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  2. D. M. Bowen
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  3. A. M. Palmer
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Editor information

Editors and Affiliations

  1. Département de Pharmacologie Biochimique, Centre de Recherche Pierre Fabre, Avenue Jean Moulin 17, 81100, Castres Cédex, France

    M. Briley

  2. Département de Pharmacologie, Centre Médical Universitaire, 1211, Geneva, Switzerland

    A. Kato

  3. Laboratoire de Pharmacologie et de Toxicologie Fondamentales, Route de Narbonne 205, 31400, Toulouse, France

    M. Weber

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Middlemiss, D.N., Bowen, D.M., Palmer, A.M. (1986). Serotonin Neurones and Receptors in Alzheimer’s Disease. In: Briley, M., Kato, A., Weber, M. (eds) New Concepts in Alzheimer’s Disease. Palgrave, London. https://doi.org/10.1007/978-1-349-08639-9_8

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  • DOI: https://doi.org/10.1007/978-1-349-08639-9_8

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