The Use of Quantitative Autoradiographic Techniques on the Study of Drug Action in the Brain: Receptor Autoradiography and 2-Deoxyglucose Technique

  • José M. Palacios
  • Karl-Heinz Wiederhold
Part of the Wenner-Gren Center International Symposium Series book series (WGS)


The main goal of pharmaceutical research is the discovery and development of new, efficacious and safe drugs for the treatment of disease. Rational drug-development is based on the understanding of the sites where drugs act and of the mechanisms involved in drug action. Sites of action for drugs are very diverse and include membrane receptors, enzymes, transport systems and others. Many physiological mechanisms can be modified as a consequence of drug action and drugs acting at different levels can lead to similar end-effects acting upon different pathways.


Glucose Uptake Thalamic Nucleus Receptor Autoradiography Substantia Nigra Compacta Lateral Habenula 
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Copyright information

© The Wenner-Gren Centre 1985

Authors and Affiliations

  • José M. Palacios
    • 1
  • Karl-Heinz Wiederhold
    • 1
  1. 1.Preclinical ResearchSandoz LtdBasleSwitzerland

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