Effects of 4-Dimethylaminoazobenzene (DAB) and 4-Cyanodimethylaniline (CDA) in the Mammalian Spot Test

  • J. W. Hart
  • R. Fahrig

Abstract

In a dose range of 50 to 200 mg/kg, both, DAB and CDA gave inconclusive results in the mammalian spot test. In nearly all cases, the frequency of colour spots was higher in the experimental sets than in the control groups, but with the exception of one experimental set, for CDA, the increases were not statistically significant.

Keywords

Recombination Dimethylformamide Arachis 

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Notes

  1. Fahrig, R. (1975). A mammalian spot test: Induction of genetic alterations in pigment cells of mouse embryos with x-rays and chemical mutagens Mol. Gen. Genet. 138: 309–314PubMedCrossRefGoogle Scholar
  2. Fahrig, R. (1977). The mammalian spot test (Fellfleckentest) with mice. Arch. Toxicol. 38: 87–98PubMedCrossRefGoogle Scholar
  3. Fahrig, R. (1984). Genetic mode of action of cocarcinogens and tumor promoters in yeast and mice. Mol. Gen. Genet. 194: 7–14PubMedCrossRefGoogle Scholar
  4. Hart, J.W., Jensen, N.J. and Larsen, S. (1982). Fluorescence microscopy as an aid in differentation of coat-colour mosaics in the mammalian spot test. Mutation Res. 105: 357–361PubMedGoogle Scholar
  5. Russell, L.B. and Major, M.H. (1957). Radiation-induced presumed somatic mutations in the house mouse. Genetics 42: 161–175PubMedPubMedCentralGoogle Scholar

Copyright information

© United Kingdom Environmental Mutagen Society 1985

Authors and Affiliations

  • J. W. Hart
    • 1
    • 3
  • R. Fahrig
    • 2
  1. 1.Leo Pharmaceutical Products LtdBallerupDenmark
  2. 2.Fraunhofer-Institut für Toxikologie Und AerosolferschungGermany
  3. 3.National Agency of Environmental ProtectionCopenhagenDenmark

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