The Induction of Mitotic Aneuploidy and Crossing-over in Yeast

  • F. Ali
  • J. M. Parry

Summary

The four test compounds BZD, DAT, DAB and CDA (Sample A) were shown to induce mitotic aneuploidy and crossing-over in yeast strain D6. All four compounds were genotoxic in yeast cells in the absence of exogenous S9 mix when tested with growing cultures showing high levels of endogenous metabolic activity.

Keywords

Toxicity DMSO NADPH Saccharomyces Kelly 

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Notes

  1. Kelly, D. and Parry, J.M. (1983). Metabolic activation of cytochrome P450/P448 in the yeast Saccharomyces cerevisiae. Mutation Res, 108: 147–159PubMedCrossRefGoogle Scholar
  2. Parry, J.M. and Zimmermann, F.K. (1976). Detection of monosomic colonies produced by mitotic non-dis junction in the yeast Sacchromyces cerevisiae. Mutation Res. 36: 49–66PubMedCrossRefGoogle Scholar
  3. Parry, J.M. and Sharp, D. (1981). Induction of mitotic aneuploidy in yeast strain D6 by 42 coded compounds. In Evaluation of Short-term Tests for Carcinogens (Progress in Mutation Research Ser. Vol.1) (eds. F.J. de Serres and J. Ashby). Elsevier/ North HollandGoogle Scholar

Copyright information

© United Kingdom Environmental Mutagen Society 1985

Authors and Affiliations

  • F. Ali
    • 1
  • J. M. Parry
    • 1
  1. 1.Department of GeneticsUniversity College of SwanseaSwanseaUK

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