The Induction of Mitotic Aneuploidy and Crossing-over in Yeast
The four test compounds BZD, DAT, DAB and CDA (Sample A) were shown to induce mitotic aneuploidy and crossing-over in yeast strain D6. All four compounds were genotoxic in yeast cells in the absence of exogenous S9 mix when tested with growing cultures showing high levels of endogenous metabolic activity.
KeywordsToxicity DMSO NADPH Saccharomyces Kelly
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- Parry, J.M. and Sharp, D. (1981). Induction of mitotic aneuploidy in yeast strain D6 by 42 coded compounds. In Evaluation of Short-term Tests for Carcinogens (Progress in Mutation Research Ser. Vol.1) (eds. F.J. de Serres and J. Ashby). Elsevier/ North HollandGoogle Scholar