Abstract
Changes along the scales of 24 hours and of development and aging in the concentration of 3 monoamines—dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT)—were studied concomitantly in different brain areas of the male Wistar rat. A circadian time effect was validated by an analysis of variance with a P≤.05 for all 3 monoamines; point-and-interval estimates of rhythm parameters were obtained by cosinor methods. By 3 months of age, a circadian rhythm was apparent for all variables and brain areas and was demonstrable up to the age of 2 years. The relative abundance of monoamines in different brain areas differed drastically, but the relative peaks and troughs of DA, NE and 5-HT in different parts of the brain occurred in rather consistent segments of the circadian period.
Along the age scale, a difference between monoamine concentrations at 3 weeks and 3 months of age is prominent. Circadian amplification and acrophase delay by 3 months of age are the major features of maturation for NE and DA, possibly as a result of maturing suprachiasmatic function. For hypothalamic 5-HT, the circadian rhythm-adjusted mean declines with age, whereas the acrophase advances during the first year of life. Relatively small changes occur at the transition from 12 to 24 months of age, probably because the animals examined were not truly senescent. A number of other statistically significant changes with age in all three neurotransmitters concerns mostly the rhythm-adjusted mean or amplitude and constitutes details of aging of circadian system structure of interest to students of aminergic neuroendocrine coordination.
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Reference
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Radha, E., Shankaraiah, K., Halberg, F., Bhaskaran, D. (1985). Developmental, Circadian and Aging Aspects of Dopamine, Norepinephrine and 5-HT in Rat Brain Regions. In: Redfern, P.H., Campbell, I.C., Davies, J.A., Martin, K.F. (eds) Circadian Rhythms in the Central Nervous System. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07837-0_17
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DOI: https://doi.org/10.1007/978-1-349-07837-0_17
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