Summary
The vertebrate retina is composed of horizontal and vertical layers that perform the tasks of visual signal perception, transformation and processing. Disk-shedding and autophagy (av) in photoreceptors follow endogenous circadian rhythms that are primarily driven by local components within the eye. Pharmacological manipulation has been used as a tool to study mechanisms of retinal rhythm regulation. Chronic clorgyline (a monoamineoxidase inhibitor) dampens the daily peak of disk-shedding and autophagy, whereas chronic methamphetamine (a dopaminergic agonist) significantly dampens only the peak of disk-shedding. Neither drug acted on the rhythm timing. Acute application of these drugs and subsequent light-stimulation of both disk-shedding and av caused a significant increase of disk-shedding, whereas no av response occured. Possibly, the light stimulation was performed at a refractory phase within the circadian rhythm of av. Drug-response as well as light-response of retinal morphology may follow a circadian rhythm of sensitivity.
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Remé, C., Wirz-Justice, A. (1985). Circadian Rhythms of the Retina and their Pharmacological Modulation. In: Redfern, P.H., Campbell, I.C., Davies, J.A., Martin, K.F. (eds) Circadian Rhythms in the Central Nervous System. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07837-0_10
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