Production and Regulation of Human T Lymphocyte Chemotactic Factor (LCF)

  • D. E. Van Epps
  • J. Potter
  • S. L. Brown
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)


The mobilisation of leukocytes to inflammatory sites is crucial to host defense. Over the years a wealth of information has evolved concerning the mechanism of leukocyte locomotion and factors with the potential specifically to attract these cells to inflammatory foci in vivo. The majority of research in this area has centred on the chemotactic response of neutrophils (PMN) and to a lesser extent on the response of monocytes and macrophages. Various naturally occurring and synthetic chemotactic factors for PMNs and monocytes have been described and they include complement fragments such as C5a (1), products of arachidonic acid metabolism such as leukotriene B4 (2), as well as other cell-derived lipids, such as acetyl glyceryl ether phosphorylcholine (platelet activating factor) (3). More recently, the neurohormones, beta-endorphin, met-enkephalin (4), and substance P (5), have been shown to stimulate mononuclear cell chemotaxis. In many cases, specific receptors for these various chemotactic factors have been defined on both PMNs and monocytes (6–10). In spite of this vast array of information on the mechanism of neutrophil and monocyte locomotion, very little is known about lymphocyte chemotaxis and the agents that are responsible for attracting these cells to sites of antigenic challenge in vivo.


Tetanus Toxoid Mixed Lymphocyte Reaction Migration Index Lymphocyte Migration Human Mononuclear Cell 
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© The Contributors 1985

Authors and Affiliations

  • D. E. Van Epps
  • J. Potter
  • S. L. Brown

There are no affiliations available

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