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The Role of the Complement-derived Polypeptide C5a in Inflammatory Reactions

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Book cover Inflammatory Mediators

Abstract

The inflammatory process is the series of responses by living tissues to injurious or potentially injurious stimuli. Following the recognition of a potentially harmful agent within the tissue, chemical messages are sent to the microvascular bed. The purpose of these messages is to promote a change in the local microenvironment such that plasma components and selected blood cells accumulate at the inflammatory focus. The functional role of this accumulation may be seen as a mechanism by which neutralisation and/or removal of the inflammatory stimulus occurs.

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Authors
  1. M. J. Forrest
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  2. P. J. Jose
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  3. T. J. Williams
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Editor information

Editors and Affiliations

  1. Department of Mediator Pharmacology, The Wellcome Research Laboratories, Beckenham, Kent, UK

    G. A. Higgs

  2. Section of Vascular Biology, Medical Research Council, Clinical Research Centre, Northwick Park, Harrow, Middlesex, UK

    T. J. Williams

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© 1985 The Contributors

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Forrest, M.J., Jose, P.J., Williams, T.J. (1985). The Role of the Complement-derived Polypeptide C5a in Inflammatory Reactions. In: Higgs, G.A., Williams, T.J. (eds) Inflammatory Mediators. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07834-9_10

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