Abstract
It has been suggested that the endogenous opioid peptides, the enkephalins and endorphins, may play a part in the development of certain psychiatric diseases. If shown to be true this would represent a major breakthrough in academic psychiatry, opening the way to alternative therapy.
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References
Akil H, Watson SJ, Sullivan S, Barchas JD. Enkephalin-like material in normal human CSF: Measurements and levels. Life Sci 23:121–126, 1978.
Bloom F, Battenberg E, Rossier J, Ling N, Leppaluoto J, Vargo TM, and Guillemin R. Endorphins are located in the intermediate and anterior lobes of the pituitary gland, not in the neurohypothysis. Life Sci 20:43–48, 1977.
Bloom F, Segal D, Ling N, and Guillemin R. Endorphins: Profound behavioral effects in rats suggest new etiological factors in mental illness. Science 194:630–632, 1976.
Burbach JPH, Loeber JG, Verhoef J, de Kloet ER, van Ree JM, de Wied D. Schizophrenia and degradation of endorphins in cerebrospinal fluid. Lancet 2:480–481, 1979.
Clement-Jones V, McLoughlin L, Lowry PJ, Besser GM, Rees LH, Wen HL. Acupuncture in heroin addicts: Changes in met-enkephalin and β-endorphin in blood and cerebrospinal fluid. Lancet 2:380–383, 1979.
Davis GC, Burney WE, De Fraites EG, Kleinman JE, van Kammen DP, Post HM, Wyatt RJ. Intravenous naloxone administration in schizophrenia and affective illness. Science 197:74–77, 1977.
de Wied D, Bohus B, van Ree JM, Kovacs GL, Greven HM. Neuroleptic-like activity of (des-tyr)-γ-endorphin in rats. Lancet 1:1046, 1978.
Domschke W, Dickshass A, Mitznegg P. CSF β-endorphin in schizophrenia. Lancet 1:1024 and Lancet 2:425, 1979.
Dupont A, Villeneuve A, Bouchard JP, Bouchard R, Merand Y, Rouleau D, and Labrie F. Rapid inactivation of enkephalin-like material by CSF in chronic schizophrenia. Lancet 2:1107, 1978.
Emrich HM, Cording C, Laspe H, Piree S, Kolling A, Moller HJ, von Zerssen D, Herz A. Actions of the opiate antagonist naloxone in psychiatric patients. Abstract, Proceedings CINP Conference, Vienna, 1978:385, 1978.
Gitlin M, Rosenblatt M. Possible withdrawal from endogenous opiates in schizophrenics. Am J Psychiat 135:377–378, 1978.
Gullemin R, Ling N, Vargo TM, Radioimmunoassays for α-endorphin and β-endorphin. Biochem Biophys Res Comm FF:361–366, 1977.
Guillemin R, Vargo TM, Rossier J, Minick S, Ling N, Rivier C, Vale W, Bloom F. β-Endorphin and adrenocorticotrophin are secreted concurrently by the pituitary gland. Science 197: 1367–1369, 1977.
Gunne LM, Lindstrom L, Terenius L. Naloxone-induced reversal of schizophrenic hallucinations. J Neural Trans 40: 13–19, 1977.
Hollt V, Przewlocki R, Herz A. β-endorphin-like immunoreactivity in plasma, pituitaries and hypothalamus of rats following treatment with opiates. Life Sci 23:1057–1066, 1978.
Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR. Identification of two related pentapeptides from the brain with potent opiate antagonist activity. Nature 258:577–579, 1975.
Janowsky D, Judd L, Huey L, Roitman N, Parker D, Segal D. Naloxone effects on manic symptoms and growth hormone levels. Lancet 2: 320, 1978.
Janowsky DS, Segal DS, Bloom F, Abrams A, Guillemin R. Lack of effect of naloxone on schizophrenic symptoms. An J Psych 134: 926–927, 1977.
Jacquet YF, Marks N. The C-fragment of β-lipotrophin: An endogenous neuroleptic or antipsychotogen? Science 194: 632–634, 1976.
Jeffcoate WJ, Rees, Lesley, McLoughlin L, Ratter SJ, Hope J, Lowry PJ, Besser GM. β-endorphin in human cerebrospinal fluid. Lancet 2:119–121, 1978.
Jeffcoate WJ. Brain peptides and pain sensation. Am Heart J (in press), 1979.
Jorgensen A, Fog R, Veilis B. Synthetic enkephalin analogue in treatment of schizophrenia. Lancet 1:935, 1979.
Kline NS, Li CH, Lehmann HE, Lajtha A, Laski E, Cooper T. β-endorphin-induced changes in schizophrenic and depressed patients. Arch Gen Psych 34:1111–1113, 1977.
Kurland AA, McCabe OL, Hanlon TE, Sullivan D. The treatment of perceptual disturbances in schizophrenia with naloxone hydrochloride. Am J Psych 134:1408–1410, 1977.
Lieberman AL. Painless myocardial infarction in psychotic patients. Geriatrics 10:579–580, 1955
Lipinski J, Meyer R, Kornetsky C, Cohen BM. Naloxone in schizophrenia: Negative result. Lancet 1:1292, 1979
Lindstrom LH, Widerlov E, Gunne IM, Wahstrom A, Terenius L. Endorphins in human cerebrospinal fluid: Clinical correlationsto some psychotic states. Acta Psych Scand 57:153–164, 1978
Marchand WE. Occurrence of painless myocardial infarction in psychotic patients. New Eng J Med 253:51–55, 1955
Marchand WE, Sarota B, Marble HD, Leary TM, Burbank CB, Bellinger MJ. Occurrence of painless acute surgical disorders in psychotic patients. New Eng J Med 260:580–585, 1959
Mielke DH, Gallant DM. An oral opiate antagonist in chronic schizophrenia: A pilot study. Am J Psych 134:1430–1431, 1977
Nakao K, Nakai Y, Oki S, Horii K, Imura H. Presence of immunoreactive, β-endorphin in normal human plasma. J Clin Invest 62:1395–013989, 1978
Orr M, Oppenheimer, C. Effects of naloxone on auditory hallucinations. Brit Med J 1:481, 1978
Sullivan S, Akil H, Watson SJ, Barchas JD. Antibodies to enkephalins: Coupling of antigens and a specific methionine-enkephalin radioimmunoassay. Commun in Psychpharmcol Vol. 1:603–610. Pergamon Press, 1977
Terenius L, Wahlsltram A, Agren H. Naloxone (Narcan) treatment in depression: Clinical observations and effects on CSF endorphins and monoamine metabolites. Psychpharmcol 54:31–33, 1977
Terenius L, Wahlstrom A, Lindstrom L, Widerlov E. Increased CSF levels of endorphins in chronic psychosis. Neurosci Lett 3:157–162, 1976
Verhoeven WMA, van Praag HM, van Ree JM, de Wied D. Improvement of schizophrenic patients treated with (des-tyr)-γ-endorphin (DPγE). Arch Gen Psych 36:294–298, 1979
Verhoeven WMA, van Praag HM, Botter PA, Sunier A, van Ree JM, de Wied D. (des-tyr)-γ-endorphin in schizophrenia. Lancet 1:1046–1047, 1978
Volavka, J., Mallya, A., Baig, S., and Perez-Cruet, J. (1977) Naloxone in chronic schizophrenia. Science, 196, 1227–1228
Watson, S.J., Berger, P.A., Akil, H., Mills, M.J., and Barchas, J.D. (1978) Effects of naloxone on schizophrenia: reduction in hallucinations in a subpopulation of subjects. Science, 201, 73–76
Yoshimi H, Matsukura S, Sueoka S, Fukase M, Yokota M, Hirata Y, Imura H.) Radioimmunoassay for β-endorphin: Presence of imnuno-reactive “big-big”β-endorphin (“big”, β-lipotrophin) in human and rat pituitaries. Life Sci 22:2189–2196, 1978
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© 1985 Spectrum Publications, Inc.
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Jeffcoate, W.J. (1985). Enkephalins, Endorphins, and Psychiatric Disease. In: Galnd, R.N., Fawzy, F.I., Hudson, B.L., Pasnau, R.O. (eds) Current Themes in Psychiatry. Palgrave, London. https://doi.org/10.1007/978-1-349-07746-5_5
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DOI: https://doi.org/10.1007/978-1-349-07746-5_5
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