Purines pp 215-221 | Cite as

The Endogenously Formed Adenosine of the Brain: Its Status as a Regulatory Signal Appraised in Relation to Actions of Homocystein

  • Henry McIlwain
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)


Adenosine is so readily formed in the brain that for some time its quantity there was overestimated by a factor of 20 or more (Berne et al. 1974; Newman and McIlwain, 1977). Now, rapid fixation methods applied to the brain and to isolated cerebral tissues adequately prepared and maintained, give values of some 1 nmole adenosine/g: about the concomitant quantity of cyclic AMP, and less than one thousandth that of the ATP. Numerous circumstances that increase the content or output of the adenosine of cerebral tissues have been observed and collated (Newman and McIlwain, 1977; Arch and Newsholme, 1978) and include ischemia, hypoxia, excitation, adrenaline, noradrenaline and glutamate. By contrast, few circumstances diminish the content or output.


Regulatory Signal Cerebral Tissue Inhibitory Tone Excitatory Action Endogenous Adenosine 
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© The Contributors 1985

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  • Henry McIlwain

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