Purines pp 125-130 | Cite as

Adenosine and the Cardiovascular System: Some of the Problems and Controversies

  • Robert M. Berne
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

Adenosine is a well known dilator of resistance vessels and probably plays an important role in the local regulation of blood flow. In the heart, administered adenosine increases coronary blood flow, and a reduction in oxygen supply or an increase in oxygen demand results in the release of adenosine and a decrease in coronary vascular resistance (Berne, 1980; Berne and Rubio, 1979). Similar observations have been made to different degrees in brain (Berne et al., 1981; Berne et al., 1983), skeletal muscle (Berne et al., 1983; Steffen et al., 1983), adipose tissue (Sollevi and Fredholm, 1981), and intestine (Granger and Norris, 1980). In the kidney adenosine produces vasoconstriction which is probably mediated via the renin-angiotensin system (Oswald, 1983), but isolated renal artery strips relax when exposed to adenosine. Finally, closure of the ductus arteriosus at birth is associated with a significant reduction in the circulating blood levels of adenosine (Mentzer et al., 1983).

Keywords

Ischemia Attenuation Adenosine Cytosol Theophylline 

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© The Contributors 1985

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  • Robert M. Berne

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