Abstract
In vivo, the regulation of dopamine (DA) synthesis in the rat striatum involves several mechanisms triggered notably by the nerve impulse flow within dopaminergic neurones and by presynaptic autoreceptors. Previous studies (1) have shown that striatal slices are an appropriate model for exploring the cellular processes which induce tyrosine hydroxylase (TH) activation in depolarized dopaminergic terminals. We have now attempted to use the same model for investigating the possible control of TH activity by an action of DA agonists and antagonists on presynaptic autoreceptors.
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References
Mestikawy, S. et al., Nature, 302: 830–832 (1983)
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© 1986 The Contributors
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el Mestikawy, S., Glowinski, J., Hamon, M. (1986). Dopaminergic Antagonists Enhance Tyrosine Hydroxylase Activation in Depolarised Striatal Slices. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_67
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DOI: https://doi.org/10.1007/978-1-349-07431-0_67
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-07433-4
Online ISBN: 978-1-349-07431-0
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