Dopaminergic Antagonists Enhance Tyrosine Hydroxylase Activation in Depolarised Striatal Slices

  • S. el Mestikawy
  • J. Glowinski
  • M. Hamon
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

In vivo, the regulation of dopamine (DA) synthesis in the rat striatum involves several mechanisms triggered notably by the nerve impulse flow within dopaminergic neurones and by presynaptic autoreceptors. Previous studies (1) have shown that striatal slices are an appropriate model for exploring the cellular processes which induce tyrosine hydroxylase (TH) activation in depolarized dopaminergic terminals. We have now attempted to use the same model for investigating the possible control of TH activity by an action of DA agonists and antagonists on presynaptic autoreceptors.

Keywords

Dopamine Tyrosine Tryptophan Haloperidol Clozapine 

References

  1. (1).
    Mestikawy, S. et al., Nature, 302: 830–832 (1983)PubMedCrossRefGoogle Scholar

Copyright information

© The Contributors 1986

Authors and Affiliations

  • S. el Mestikawy
    • 1
  • J. Glowinski
    • 1
  • M. Hamon
    • 1
  1. 1.College de France, Group NBINSERM U114ParisFrance

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