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MPTP Infusion into Rat Substantia Nigra Causes Hypokinesia and Bradykinesia which are Reversed by L-Dopa Treatment

  • A. J. Bradbury
  • B. Costall
  • A. M. Domeney
  • P. Jenner
  • C. D. Marsden
  • R. J. Naylor
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)

Abstract

Motor deficits and neurochemical change resembling those of Parkinson’s disease are caused by peripherally administered 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in man and monkey (see Langston et al, 1984) but with difficulty in the rodent (Chiueh et al, 1983; Boyce et al, 1984). We report here that MPTP can cause persistent motor deficits and neurochemical change when it is delivered directly into the substantia nigra (SN) of rat brain by continuous infusion.

Keywords

Substantia Nigra Motor Deficit Homovanillic Acid Neurochemical Change Neurotoxic Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Boyce, S., Kelly, E., Reavill, C., Jenner, P. and Marsden, C.D. (1984). Repeated administration of N-methyl-4-phenyl 1,2,5,6-tetrahydropyridine to rats is not toxic to striatal dopamine neurones. Biochem. Pharmacol., 33, (11) 1747–1752.PubMedCrossRefGoogle Scholar
  2. Chiueh, C.C., Markey, S.P., Burns, R.S., Johannessen, J., Jacobowitz, D.M. and Kopin, I.J. (1983). N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a Parkinsonian syndrome causing agent in man and monkey, produces different effects in guinea pig and rat. Pharmacologist, 25, 131.Google Scholar
  3. De Groot, J. (1959). The rat forebrain in stereotaxic co-ordinates. Verh. K.Ned.Akad.Wet., 52, 14–39.Google Scholar
  4. Langston, J.W., Forno, L.S., Rebert, C.S. and Irwin, I. (1984). Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey.Google Scholar
  5. This work was supported by the S.E.R.C. and the Wellcome Trust.Google Scholar

Copyright information

© The Contributors 1986

Authors and Affiliations

  • A. J. Bradbury
    • 1
  • B. Costall
    • 1
  • A. M. Domeney
    • 1
  • P. Jenner
    • 2
  • C. D. Marsden
    • 2
  • R. J. Naylor
    • 1
  1. 1.Postgraduate School of Studies in PharmacologyUniversity of BradfordBradfordUK
  2. 2.University Department of Neurology and Parkinson’s Disease Research CentreInstitute of Psychiatry and King’s College Hospital Medical SchoolDenmark HillUK

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