MPTP Infusion into Rat Substantia Nigra Causes Hypokinesia and Bradykinesia which are Reversed by L-Dopa Treatment
Motor deficits and neurochemical change resembling those of Parkinson’s disease are caused by peripherally administered 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in man and monkey (see Langston et al, 1984) but with difficulty in the rodent (Chiueh et al, 1983; Boyce et al, 1984). We report here that MPTP can cause persistent motor deficits and neurochemical change when it is delivered directly into the substantia nigra (SN) of rat brain by continuous infusion.
KeywordsToxicity HPLC Dopamine Cage Serotonin
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- This work was supported by the S.E.R.C. and the Wellcome Trust.Google Scholar