Modulatory Role of Prolactin in the Development of an Elevated Density of Striatal Dopamine Receptors after the Chronic Administration of Domperidone or Sulpiride

  • R. E. Hruska
Part of the Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology book series (SSNIC)


Haloperidol (HAL) blocks dopamine (CA) receptors. This activity at pituitary DA receptors elicits an elevation in prolactin (PRL) secretion and synthesis, while at striatal DA receptors after long-term administration it produces an increased density. These two actions had been assumed to be unrelated.


Receptor Density Modulative Role Receptor Supersensitivity Elevated Density Striatal Dopamine Receptor 
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  1. Hruska, R.E. and Pitman, K.T. (1982). Hypophysectomy reduces the haloperidol-induced changes in striatal dopamine receptor density. Eur. J. Pharmacol., 85, 201–205.PubMedCrossRefGoogle Scholar
  2. Rupniak, N., Hong, M., Mansfield, S., Fleminger, S., Dyer, R., Jenner, P., and Marsden, C.D. (1983). Elevation of circulating prolactin concentrations may not cause striatal dopamine receptor supersensitivity. Eur. J. Pharmacol., 93, 195–200.PubMedCrossRefGoogle Scholar

Copyright information

© The Contributors 1986

Authors and Affiliations

  • R. E. Hruska
    • 1
  1. 1.Department of Biochemical PharmacologyState University of New York at BuffaloBuffaloUSA

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