Abstract
Ergolines are structurally complex dopamine agonists and their pharmacological effects are obscured by possible participation of α1-, α2-adrenoceptor activation and/or serotonin (5-HT1/5-HT2) receptor stimulation, which may also explain various side effects of these drugs (McPherson and Beart, 1983). This non-selectivity also occurs in the more recently introduced oxaergolines such as RU 29717 (Boissier et al., 1983), although to a lesser extent. Thus there is an increasing need for developing potent dopamine agonists showing a selectivity for DA receptors as compared to their affinity for other receptor types.
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References
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Hazelhoff, B. et al. (1986). Neuropharmacological Profile of a New Series of Dopamine Agonists: N-n-Propyl-hexahydronaphthoxazines. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_28
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DOI: https://doi.org/10.1007/978-1-349-07431-0_28
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