Skip to main content
SpringerLink
Log in
Book cover

Dopaminergic Systems and their Regulation pp 293–302Cite as

Palgrave Macmillan

Separate Molecular Mechanisms for Estrogen-induced Up- and Down-regulation of Striatal Dopamine Receptors

  • Chapter

  • 192 Accesses

Abstract

The changes in striatal dopamine receptor sensitivity and/or density following the administration of estrogen are dependent upon both the dose of the hormone and the time post-injection (Gordon, 1980). Classically the modulatory effects of estrogen on behavior, in the rat, require 18-24 hours from the time of hormone administration before they are expressed (Harlan et al., 1979). This delay is thought to represent the estrogen-induced synthesis and/or axonal transport of specific proteins in the central nervous system (CNS). Using this time frame (i.e. 24 hours post-injection), several investigators have demonstrated a down-regulation or desensitization of striatal dopamine receptors following estrogen administration (Bedard et al., 1978; Euvrard et al., 1979; Gordon, 1980; Gordon et al., 1980). However, longer periods of time (i.e. 48 hours or longer post-injection) result in an up-regulation of striatal dopamine receptors. It should be noted however, that this up-regulation is seen only following the administration of high doses of estrogen (Chiodo et al., 1979; Gordon, 1980; Hruska and Silbergeld, 1980; Nausieda et al., 1979)

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anders, M. W. (1968). Inhibition of microsomal drug metabolism by methylenedioxybenzenes. Biochem. Pharmacol., 17, 2367–2370

    Article  PubMed  CAS  Google Scholar 

  • Ball, P., Haupt, M. and Knuppen, R. (1978). Comparative studies on the metabolism of oestradiol in the brain, the pituitary and the liver of the rat. Acta Endocrinol., 87, 1–11

    PubMed  CAS  Google Scholar 

  • Ball, P. and Knuppen, R. (1978). Formation of 2- and 4-hydroxyestrogens by brain, pituitary and liver of the human fetus. J. Clin. Endocr. Metab., 47, 732–737

    Article  PubMed  CAS  Google Scholar 

  • Ball, P. and Knuppen, R. (1980). Catecholestrogens (2- and 4-hydroxyestrogens). Chemistry, biogenesis, metabolism, occurrence and physiological significance. Acta Endocrinol. (Suppl.) 232, 1–127

    CAS  Google Scholar 

  • Barbieri, R. L., Camick, J. A. and Ryan, K. J. (1978). Estrogen 2-hydroxylase: Activity in rat tissue. Steriods, 32, 529–538

    Article  CAS  Google Scholar 

  • Bedard, P., DanKova, J., Boucher, R. and Langelier, P. (1978). Effect of estrogen on apomorphine-induced circling behavior in the rat. Canad. J. Physiol. Pharmacol., 56, 538–541

    Article  CAS  Google Scholar 

  • Chiodo, L. A., Caggiula, A. R. and Saller, C. F. (1979). Estrogen increases both spiperone-induced catalepsy and brain levels of 3H-spiperone in rat. Brain Res., 172, 360–365

    Article  PubMed  CAS  Google Scholar 

  • Chiodo, L. A., Caggiula, A. R. and Saller, C. F. (1981). Estrogen potentiates the stereotypy induced by dopamine agonists in the rat. Life Sci., 28, 827–835

    Article  PubMed  CAS  Google Scholar 

  • Deming, W. E. (1943) Stastical Adjustment of Data. John Wiley and Sons, Inc., New York.

    Google Scholar 

  • Euvrard, C., Labrie, F. and Boissier, J. R. (1979). Effect of estrogen on changes in the activity of striatal cholinergic neurons induced by DA drugs. Brain Res., 169, 215–220

    Article  PubMed  CAS  Google Scholar 

  • Euvrard, C., Oberlander, C. and Boissier, J. R. (1980). Antidopaminergic effect of estrogens at the striatal level. J. Pharmacol. exp. Ther., 214, 179–185

    PubMed  CAS  Google Scholar 

  • Fields, J. Z., Reisine, T. D. and Yamamura, H. I. (1977). Biochemical demonstration of dopaminergic receptors in rat and human brain using [3H]-spiroperidol. Brain Res., 136, 578–584

    Article  PubMed  CAS  Google Scholar 

  • Finney, D. J. (1971) Probit Analysis, 3rd edn. Cambridge University Press, London.

    Google Scholar 

  • Fishman, J. (1963). Role of 2-hydroxyestrone in estrogen metabolism. J. Clin. Endocr. Metab., 23, 207–210

    Article  PubMed  CAS  Google Scholar 

  • Fishman, J. and Norton, B. (1975). Catechol estrogen formation in the central nervous system of the rat. Endocrinology, 96, 1054–1059

    Article  PubMed  CAS  Google Scholar 

  • Fishman J., Naftolin, F., Davies, I. J., Rayan, K. J. and Petro, Z. (1976). Catecholestrogen formation by the human fetal brain and pituitary. J. Clin. Endocr. Metab., 42, 177–180

    Article  PubMed  CAS  Google Scholar 

  • Fishman, J. (1976). The catechol estrogens. Neuroendocrinology, 22, 363–374

    Article  PubMed  CAS  Google Scholar 

  • Foreman M. M. and Porter, J. C. (1980). Effects of catechol estrogens and catecholamines on hypothalamic and corpus striatal tyrosine hydroxylase activity. J. Neurochem., 34, 1175–1183

    Article  PubMed  CAS  Google Scholar 

  • Gordon, J. H. (1980). Modulation of apomorphine-induced stereotypy by estrogen: Time course and dose response. Brain Res. Bull., 5, 679–682

    Article  CAS  Google Scholar 

  • Gordon, J. H., Gorski, R. A., Borison, R. L. and Diamond, B. I. (1980). Postsynaptic efficacy of dopamine: Possible suppression by estrogen. Pharmacol. Biochem. Behav., 12, 515–518

    Article  PubMed  CAS  Google Scholar 

  • Gordon, J. H. and Perry, K. O. (1983). Pre- and postsynaptic neurochemical alterations following estrogen-induced striatal dopamine hypo- and hypersensitivity. Brain Res. Bull., 10, 425–428

    Article  CAS  Google Scholar 

  • Gordon, J. H. and Diamond, B. I. (1984). Enhancement of hypophysectomy-induced dopamine receptor hypersensitivity in male rats by chronic haloperidol administration. J. Neurochem., 42, 523–528

    Article  PubMed  CAS  Google Scholar 

  • Haley, T. J. (1978). Piperonyl butoxide, alpha (2-(2-butoxy-ethoxy) ethoxy)4–5-methylene-2-propyltoluene: A review of the literature. Ecotoxicol. Environ. Safety, 2, 9–31

    Article  PubMed  CAS  Google Scholar 

  • Harlan, R. E., Gordon, J. H. and Gorski, R. A. (1979). Sexual differentiation of the brain: Implications for neuroscience. In Reviews of Neuroscience Vol. 4. (ed. D. M. Schneider) Raven Press, New York.

    Google Scholar 

  • Hersey, R. M., Lloyd, T., MacLusky, N. J. and Weisz, J. (1982). The catechol estrogen, 2-hydroxyestradiol-17a, is formed from estradiol-17a by hypothalamic tissue in vitro and inhibits tyrosine hydroxylase. Endocrinology, 111, 1734–1736

    Article  PubMed  CAS  Google Scholar 

  • Hoppen, H.-O., Ball. P., Hoogen, H. and Knuppen, R. (1973). Metabolism of 2-hydroxyoestrogen methyl ethers in the rat liver in vitro. Hoppe-Seyler’s Z. Physiol. Chem., 354, 771–780

    Article  CAS  Google Scholar 

  • Hruska, R. E. and Silbergeld, E. K. (1980). Estrogen treatment enhances dopamine receptor sensitivity in rat striatum. Europ. J. Pharmacol., 61, 397–400

    Article  CAS  Google Scholar 

  • Hruska, R. E., Ludmer, L. M. and Silbergeld, E. K. (1980). Characterization of the striatal dopamine receptor supersensitivity produced by estrogen treatment of male rats. Neuropharmacology, 19, 923–926

    Article  PubMed  CAS  Google Scholar 

  • Hruska, R. E., Pitman, K. T. and Silbergeld, E. K. (1982). Prolactin increases the density of striatal dopamine receptors in normal and hypophysectomized male rats. Life Sci., 30, 547–553

    Article  PubMed  CAS  Google Scholar 

  • Jenner, P., Rupniak, N. M. J., Hall, M. D., Dyer, R., Leigh, N. and Marsden, C. D. (1981). Hypophysectomy does not prevent development of striatal dopamine receptor supersensitivity induced by repeated neuroleptic treatment. Eur. J. Pharmacol., 76, 31–36

    Article  PubMed  CAS  Google Scholar 

  • Kono, S., Brandon, D. D., Merriam, G. R., Loriaux, D. L. and Lipsett, M. B. (1981). Metabolic clearance rate and uterotropic activity of 2-hydroxyestrone in rats. Endocrinology, 108, 40–43

    Article  PubMed  CAS  Google Scholar 

  • Lloyd, T. and Weisz, J. (1978). Direct inhibition of tyrosine hydroxylase activity by catechol estrogens. J. biol. Chem., 253, 4841–4843

    PubMed  CAS  Google Scholar 

  • Lundeen, J. E. and Gordon, J. H. (1983). A user friendly computer program for the analysis of ligand binding data. Soc. Neurosci. Abstr., 9, 1112

    Google Scholar 

  • MacLusky, N. J., Naftolin, F., Krey, L. C. and Franks, S. (1981). The catechol estrogens. J. Steriod Biochem., 15, 111–124

    Article  CAS  Google Scholar 

  • Nausieda, P. A., Koller, W. E., Weiner, W. J. and Klawans, H. L. (1979). Modification of postsynaptic dopaminergic sensitivity by female sex hormones Life Sci., 25, 521–526

    Google Scholar 

  • Parvizi, N. and Wuttke, W. (1983). Catecholestrogens affect catecholamine turnover rates in the anterior part of the mediobasal hypothalamus and medial preoptic area in the male and female castrated rat. Neuroendocrinology, 36, 21–26

    Article  PubMed  CAS  Google Scholar 

  • Paul, S. M. and Axelrod, J. (1977a). Catechol estrogens: Presence in brain and endocrine tissues. Science, 197, 657–659

    Article  PubMed  CAS  Google Scholar 

  • Paul, S. M. and Axelrod, J. (1977b). A rapid and sensititive radioenzymatic assay for catechol estrogens in tissues. Life Sci., 21, 493–502

    Article  PubMed  CAS  Google Scholar 

  • Paul, S. M., Axelrod, J. and Diliberto, E. J. Jr. (1977). Catechol estrogen-forming enzyme of brain: Demonstration of a cytochrome P-450 monooxygenase. Endocrinology, 101, 1604–1610

    Article  PubMed  CAS  Google Scholar 

  • Pedigo, N. W., Reisine, T. D., Fields, J. Z. and Yamamura, H. I. (1978). [3H]-spiroperidol binding to two receptor sites in both corpus striatum and frontal cortex of rat brain. Europ. J. Pharmacol., 50, 451–453

    Google Scholar 

  • Perry, K. O., Diamond, B. I., Fields, J. Z. and Gordon, J. H. (1981). Hypophysectomy induced hypersensitivity to dopamine: Antagonism by estrogen. Brain Res., 226, 211–219

    Article  PubMed  CAS  Google Scholar 

  • Reddy, V. R. and Rajan, R. (1978). Catecholestrogens formation in male and female rats’ brain. J. Steriod Biochem., 9, 881 (Abst.)

    Article  Google Scholar 

  • Reddy, V. V. R., Rajan, R. and Daly, M. J. (1981). Oestrogen metabolism in adult rat’s brain. Acta Endocrinol., 96, 7–14

    PubMed  CAS  Google Scholar 

  • Robbins, T. W. (1977). A critique of the methods available for measuring spontaneous motor activity. In Handbook of Psychopharmacology Vol. 7. (eds. L. Iverson, S. Iverson and S. Snyder). Plenum Publishing Corp., New York.

    Google Scholar 

  • Sasame, H. A., Ames, M. M. and Nelson, S. D. (1977). Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: Formation of catechols and reactive catecholmetabolites. Biochem. Biophys. Res. Commun., 78, 919–926

    Article  PubMed  CAS  Google Scholar 

  • Shellenberger, M. K. and Gordon, J. H. (1971). A rapid simplified procedure for simultaneous assay of norepinephrine, dopamine and 5-hydroxytryptamine from discrete brain areas. Anal. Biochem., 39, 356–372

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. J. K. Clopton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. H. Gordon
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK

    G. N. Woodruff (Director of Pharmacology) (Director of Pharmacology)

  2. Department of Physiology and Pharmacology, University of Southampton, UK

    J. A. Poat  & P. J. Roberts  & 

Copyright information

© 1986 The Contributors

About this chapter

Cite this chapter

Clopton, J.K., Gordon, J.H. (1986). Separate Molecular Mechanisms for Estrogen-induced Up- and Down-regulation of Striatal Dopamine Receptors. In: Woodruff, G.N., Poat, J.A., Roberts, P.J. (eds) Dopaminergic Systems and their Regulation. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07431-0_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-349-07431-0_20

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-07433-4

  • Online ISBN: 978-1-349-07431-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation