Dopamine Release and Metabolism in Awake Rats after Systemic Neuroleptics as Studied by Brain Dialysis
Drugs which block central dopamine (DA)-receptors (neuroleptics) are known to stimulate the synthesis and the metabolism of DA (Carlsson and Lindquist, 1963; Javoy et al., 1970; Andén et al., 1971) and the firing activity of DA-neurons (Bunney et al., 1973). Such effects have been taken as evidence for the existence of feedback or autoregulatory mechanism in the dopaminergic system (Carlsson and Lindquist, 1963; Carlsson, 1975; Bunney and Aghajanian, 1976). According to this hypothesis the functional activity of the DA-neurons is negatively regulated by the amount of DA released from DA-terminals or dendrites (Bjorklund and Lindvall, 1975; Geffen et al., 1976; Korf et al., 1976; Nieoullon et al., 1977) onto DA-receptors located either post-synaptically in the caudate (Carlsson and Lindquist, 1963; Bunney and Aghajanian, 1976) or on non-dopaminergic terminals of the substantia nigra (Phillipson and Horn, 1976; Spano et al., 1976; Spano et al., 1977) or on the DA-neurons themselves, either in the caudate (terminal auto-receptors) (Carlsson, 1975), or in the nigra (nigral auto-receptors) (Aghajanian and Bunney, 1977).
KeywordsDopamine Morphine Haloperidol Amphetamine Lactone
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